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Tytuł:
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100 Years Later, What Is New in Glycerol Bioproduction?
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Autorzy:
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Semkiv MV; Department of Molecular Genetics and Biotechnology, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Street 14/16, Lviv 79005, Ukraine.
Ruchala J; Department of Molecular Genetics and Biotechnology, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Street 14/16, Lviv 79005, Ukraine; Department of Microbiology and Molecular Genetics, University of Rzeszów, Zelwerowicza 4, Rzeszów 35-601, Poland.
Dmytruk KV; Department of Molecular Genetics and Biotechnology, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Street 14/16, Lviv 79005, Ukraine.
Sibirny AA; Department of Molecular Genetics and Biotechnology, Institute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Street 14/16, Lviv 79005, Ukraine; Department of Microbiology and Molecular Genetics, University of Rzeszów, Zelwerowicza 4, Rzeszów 35-601, Poland. Electronic address: .
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Źródło:
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Trends in biotechnology [Trends Biotechnol] 2020 Aug; Vol. 38 (8), pp. 907-916. Date of Electronic Publication: 2020 Mar 12.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Publication: Barking : Elsevier Science Publishers
Original Publication: [Amsterdam, Netherlands : Elsevier Science Publishers B.V. (Biomedical Division), c1983-
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MeSH Terms:
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Metabolic Engineering*
Carbohydrate Metabolism/*genetics
Glycerol/*metabolism
Saccharomyces cerevisiae/*genetics
Anaerobiosis/genetics ; Ethanol/chemistry ; Ethanol/metabolism ; Fermentation ; Glucose/genetics ; Glycerol/chemistry ; Humans ; Saccharomyces cerevisiae/metabolism
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Contributed Indexing:
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Keywords: Neuberg fermentation; S. cerevisiae; anaerobic glycerol production; glycerol; glycerol from CO(2); metabolic engineering
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Substance Nomenclature:
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3K9958V90M (Ethanol)
IY9XDZ35W2 (Glucose)
PDC6A3C0OX (Glycerol)
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Entry Date(s):
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Date Created: 20200626 Date Completed: 20210715 Latest Revision: 20210715
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Update Code:
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20240105
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DOI:
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10.1016/j.tibtech.2020.02.001
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PMID:
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32584768
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Industrial production of glycerol by yeast, which began during WWI in the so-called Neuberg fermentation, was the first example of metabolic engineering. However, this process, based on bisulfite addition to fermentation liquid, has many drawbacks and was replaced by other methods of glycerol production. Osmotolerant yeasts and other microorganisms that do not require addition of bisulfite to steer cellular metabolism towards glycerol synthesis have been discovered or engineered. Because the glycerol market is expected to reach 5 billion US$ by 2024, microbial fermentation may again become a promising way to produce glycerol. This review summarizes some problems and perspectives on the production of glycerol by natural or engineered eukaryotic and prokaryotic microorganisms.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
