Generation of induced pluripotent stem cells from large domestic animals.

Tytuł:: Generation of induced pluripotent stem cells from large domestic animals.
Autorzy:: Bressan FF; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil. .; Postgraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil. .; Center for Cell-Based Therapy, Regional Blood Center, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. .
Bassanezze V; Heart Institute (INCOR), Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Present Address: Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
de Figueiredo Pessôa LV; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.; Postgraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Sacramento CB; Heart Institute (INCOR), Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Present Address: Weill Cornell Medicine, Cornell University, Ithaca, USA.
Malta TM; Center for Cell-Based Therapy, Regional Blood Center, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Kashima S; Center for Cell-Based Therapy, Regional Blood Center, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Fantinato Neto P; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.; Postgraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Strefezzi RF; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Pieri NCG; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
Krieger JE; Heart Institute (INCOR), Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Covas DT; Center for Cell-Based Therapy, Regional Blood Center, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Meirelles FV; Department of Veterinary Medicine, Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.; Postgraduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.; Center for Cell-Based Therapy, Regional Blood Center, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Źródło:: Stem cell research & therapy [Stem Cell Res Ther] 2020 Jun 25; Vol. 11 (1), pp. 247. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central
MeSH Terms:: Induced Pluripotent Stem Cells*
Animals ; Animals, Domestic ; Cattle ; Cell Differentiation ; Cellular Reprogramming ; Embryonic Stem Cells ; Fibroblasts ; Horses ; Kruppel-Like Factor 4 ; Kruppel-Like Transcription Factors/genetics ; Mice ; Octamer Transcription Factor-3/genetics ; SOXB1 Transcription Factors/genetics
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Contributed Indexing:: Keywords: Bovine; Cellular reprogramming; Equine; Induced pluripotency; iPSCs; stem cells
Substance Nomenclature:: 0 (KLF4 protein, human)
0 (Klf4 protein, mouse)
0 (Kruppel-Like Factor 4)
0 (Kruppel-Like Transcription Factors)
0 (Octamer Transcription Factor-3)
0 (SOXB1 Transcription Factors)
Entry Date(s):: Date Created: 20200627 Date Completed: 20210618 Latest Revision: 20240329
Update Code:: 20240329
PubMed Central ID:: PMC7318412
DOI:: 10.1186/s13287-020-01716-5
PMID:: 32586372
: Czasopismo naukowe

Pełny tekst

Background: Induced pluripotent stem cells (iPSCs) have enormous potential in developmental biology studies and in cellular therapies. Although extensively studied and characterized in human and murine models, iPSCs from animals other than mice lack reproducible results.
Methods: Herein, we describe the generation of robust iPSCs from equine and bovine cells through lentiviral transduction of murine or human transcription factors Oct4, Sox2, Klf4, and c-Myc and from human and murine cells using similar protocols, even when different supplementations were used. The iPSCs were analyzed regarding morphology, gene and protein expression of pluripotency factors, alkaline phosphatase detection, and spontaneous and induced differentiation.
Results: Although embryonic-derived stem cells are yet not well characterized in domestic animals, generation of iPS cells from these species is possible through similar protocols used for mouse or human cells, enabling the use of pluripotent cells from large animals for basic or applied purposes. Herein, we also infer that bovine iPS (biPSCs) exhibit similarity to mouse iPSCs (miPSCs), whereas equine iPSs (eiPSCs) to human (hiPSCs).
Conclusions: The generation of reproducible protocols in different animal species will provide an informative tool for producing in vitro autologous pluripotent cells from domestic animals. These cells will create new opportunities in animal breeding through transgenic technology and will support a new era of translational medicine with large animal models.

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