A prospective community engagement initiative to improve clinical research participation in patients with peripheral artery disease.

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Abstrakt

Tytuł:: A prospective community engagement initiative to improve clinical research participation in patients with peripheral artery disease.
Autorzy:: Levenberg K; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.; Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.
Proctor DN; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.; Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.
Maman SR; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.
Luck JC; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.
Miller AJ; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.
Aziz F; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.
Radtka JF 3rd; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.
Muller MD; Heart and Vascular Institute, College of Medicine, Penn State University, Hershey, PA, USA.; Department of Anesthesiology and Perioperative Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Master of Science in Anesthesia Program, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Źródło:: SAGE open medicine [SAGE Open Med] 2020 Jun 13; Vol. 8, pp. 2050312120930915. Date of Electronic Publication: 2020 Jun 13 (Print Publication: 2020).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : SAGE Publications
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Grant Information:: KL2 TR002015 United States TR NCATS NIH HHS; R21 AG054940 United States AG NIA NIH HHS; UL1 TR002014 United States TR NCATS NIH HHS
Contributed Indexing:: Keywords: Advertising; aging; atherosclerosis; barriers to clinical trial enrollment; cardiovascular health; exercise therapy; lower extremity blood supply
Entry Date(s):: Date Created: 20200627 Latest Revision: 20220928
Update Code:: 20240105
PubMed Central ID:: PMC7294489
DOI:: 10.1177/2050312120930915
PMID:: 32587692
: Czasopismo naukowe

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Objective: Patients diagnosed with peripheral artery disease are difficult to recruit into clinical trials. However, there is currently no high-quality, patient-centered information explaining why peripheral artery disease patients choose to participate or not participate in clinical research studies.
Methods: The current study was a prospective community engagement initiative that specifically asked patients with and without peripheral artery disease: (1) what motivates them to participate in clinical research studies, (2) their willingness to participate in different research procedures, (3) the barriers to participation, (4) preferences about study design, and (5) demographic and disease-related factors influencing participation. Data were gathered through focus groups ( n = 19, participants aged 55-79 years) and mailed questionnaires ( n = 438, respondents aged 18-85 years).
Results: More than half of the respondents stated that they would be willing to participate in a study during evening or weekend time slots. Peripheral artery disease patients ( n = 45) were more willing than those without peripheral artery disease ( n = 360) to participate in drug infusion studies (48% versus 18%, p < 0.001) and trials of investigational drugs (44% versus 21%, p < 0.001). Motivating factors and barriers to participation were largely consistent with previous studies.
Conclusion: Adults in our geographic region are interested in participating in clinical research studies related to their health; they would like their doctor to tell them what studies they qualify for and they prefer to receive a one-page advertisement that has color pictures of the research procedures. Peripheral artery disease patients are more willing than those without peripheral artery disease to participate in drug infusion studies, trials of investigational drugs, microneurography, and spinal/epidural infusions.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2020.)

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