Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.

Tytuł:: Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells.
Autorzy:: Nakano T; DNA Damage Chemistry Research Group, Institute for Quantum Life Science, Kansai Photon Science Institute, National Institutes of Quantum and Radiological Science and Technology, Kizugawa, Kyoto, Japan.; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Shoulkamy MI; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Tsuda M; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sasanuma H; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hirota K; Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
Takata M; Department of Late Effects Studies, Radiation Biology Center, Kyoto University, Kyoto, Japan.
Masunaga SI; Division of Radiation Life Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan.
Takeda S; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ide H; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan.
Bessho T; The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Tano K; Division of Radiation Life Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan.
Źródło:: PloS one [PLoS One] 2020 Jun 26; Vol. 15 (6), pp. e0234859. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: DNA Repair*
DNA/*metabolism
DNA Topoisomerases, Type I/*metabolism
Formaldehyde/*toxicity
Phosphoric Diester Hydrolases/*metabolism
Animals ; Cell Line ; Chickens ; Chromosome Breakage/drug effects ; DNA/chemistry ; DNA Breaks/drug effects ; DNA Breaks, Double-Stranded/drug effects ; DNA Topoisomerases, Type I/chemistry ; Decitabine/toxicity ; Mitomycin/toxicity ; Phosphoric Diester Hydrolases/genetics
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Substance Nomenclature:: 1HG84L3525 (Formaldehyde)
50SG953SK6 (Mitomycin)
776B62CQ27 (Decitabine)
9007-49-2 (DNA)
EC 3.1.4.- (Phosphoric Diester Hydrolases)
EC 5.99.1.2 (DNA Topoisomerases, Type I)
Entry Date(s):: Date Created: 20200627 Date Completed: 20200909 Latest Revision: 20200909
Update Code:: 20240105
PubMed Central ID:: PMC7319324
DOI:: 10.1371/journal.pone.0234859
PMID:: 32589683
: Czasopismo naukowe

Pełny tekst

Proteins are covalently trapped on DNA to form DNA-protein cross-links (DPCs) when cells are exposed to DNA-damaging agents. Aldehyde compounds produce common types of DPCs that contain proteins in an undisrupted DNA strand. Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs topoisomerase 1 (TOPO1) that is trapped at the 3'-end of DNA. In the present study, we examined the contribution of TDP1 to the repair of formaldehyde-induced DPCs using a reverse genetic strategy with chicken DT40 cells. The results obtained showed that cells deficient in TDP1 were sensitive to formaldehyde. The removal of formaldehyde-induced DPCs was slower in tdp1-deficient cells than in wild type cells. We also found that formaldehyde did not produce trapped TOPO1, indicating that trapped TOPO1 was not a primary cytotoxic DNA lesion that was generated by formaldehyde and repaired by TDP1. The formaldehyde treatment resulted in the accumulation of chromosomal breakages that were more prominent in tdp1-deficient cells than in wild type cells. Therefore, TDP1 plays a critical role in the repair of formaldehyde-induced DPCs that are distinct from trapped TOPO1.
Competing Interests: The authors have declared that no competing interests exist.

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