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Tytuł pozycji:

Sickle cell trait and the potential risk of severe coronavirus disease 2019-A mini-review.

Tytuł :
Sickle cell trait and the potential risk of severe coronavirus disease 2019-A mini-review.
Autorzy :
Kehinde TA; Central and Northwest London NHS Foundation Trust, Kingswood Centre, London, UK.
Osundiji MA; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
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Źródło :
European journal of haematology [Eur J Haematol] 2020 Nov; Vol. 105 (5), pp. 519-523. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Publication: <2005->: Oxford : Blackwell
Original Publication: Copenhagen : Munksgaard, c1987-
MeSH Terms :
COVID-19/*complications
Sickle Cell Trait/*complications
African Americans/genetics ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/genetics ; COVID-19/epidemiology ; COVID-19/mortality ; Humans ; Pandemics ; Precision Medicine ; Risk Factors ; SARS-CoV-2 ; Sickle Cell Trait/epidemiology ; Sickle Cell Trait/genetics ; United States/epidemiology
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Contributed Indexing :
Keywords: Thromboembolism; Vaso-Occlusive Crisis (VOC); acute chest syndrome; coronavirus disease 2019; sickle cell disease; sickle cell trait
Entry Date(s) :
Date Created: 20200627 Date Completed: 20201211 Latest Revision: 20210110
Update Code :
20210210
PubMed Central ID :
PMC7361772
DOI :
10.1111/ejh.13478
PMID :
32589774
Czasopismo naukowe
Coronavirus Disease 2019 (COVID-19) pandemic is a rapidly evolving public health problem. The severity of COVID-19 cases reported hitherto has varied greatly from asymptomatic to severe pneumonia and thromboembolism with subsequent mortality. An improved understanding of risk factors for adverse clinical outcomes may shed some light on novel personalized approaches to optimize clinical care in vulnerable populations. Emerging trends in the United States suggest possibly higher mortality rates of COVID-19 among African Americans, although detailed epidemiological study data is pending. Sickle cell disease (SCD) disproportionately affects Black/African Americans in the United States as well as forebearers from sub-Saharan Africa, the Western Hemisphere (South America, the Caribbean, and Central America), and some Mediterranean countries. The carrier frequency for SCD is high among African Americans. This article underscores the putative risks that may be associated with COVID-19 pneumonia in sickle cell trait as well as potential opportunities for individualized medical care in the burgeoning era of personalized medicine.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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