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Tytuł pozycji:

GLI1 expression in pancreatic ductal adenocarcinoma correlates the clinical significance and prognosis: A meta-analysis.

Tytuł:
GLI1 expression in pancreatic ductal adenocarcinoma correlates the clinical significance and prognosis: A meta-analysis.
Autorzy:
Li R; Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy.
Liu Z; Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy.
Chen Y; Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy.
Hu X; Department of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Peng X; Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy.
Źródło:
Medicine [Medicine (Baltimore)] 2020 Jun 26; Vol. 99 (26), pp. e20950.
Typ publikacji:
Journal Article; Meta-Analysis; Systematic Review
Język:
English
Imprint Name(s):
Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:
Prognosis*
Carcinoma, Pancreatic Ductal/*enzymology
Zinc Finger Protein GLI1/*analysis
Adenocarcinoma/enzymology ; Adenocarcinoma/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Carcinoma, Pancreatic Ductal/genetics ; Humans
References:
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Guo JF, Li ZS, Jin ZD, et al. mRNA expression of GLI1 in pancreatic carcinoma and clinical significance thereof[J]. Natl Med J China 2007;87:826–8.
Zhou HP, Shen ZL. Expression of Plexin-B1 and Gli1 in PDAC tissues and its clinicopathological significance [J]. Zhejiang Med J 2018;40:937–72.
Jiang H, Li F, He C, et al. Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of PDAC[J]. Int J Clin Exp Pathol 2014;7:4531.
Wen B, Xu ML, Li SQ, et al. Expression of glioma—associated oncogene 1 and CDl05 in PDAC and its relationship with the clinicopathologiical characteristic[J]. Chin J Exp Surg 2015;32:1710–2.
Chen WZ, Liu GC, Zang H, et al. Study on the expression and clinical pathological significances of GLI 1 and MMP 9 in pancreatic carcinoma. Med J Liaon 2015;207–11.
Abula Y, Yi C, Wang XY, et al. Gli1 expression in pancreatic ductal adenocarcinoma and its clinical significance. Genet Mol Res 2015;14:12323–9.
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Substance Nomenclature:
0 (Biomarkers, Tumor)
0 (GLI1 protein, human)
0 (Zinc Finger Protein GLI1)
Entry Date(s):
Date Created: 20200627 Date Completed: 20200707 Latest Revision: 20210309
Update Code:
20240105
PubMed Central ID:
PMC7329021
DOI:
10.1097/MD.0000000000020950
PMID:
32590806
Czasopismo naukowe
Background: Glioma-associated oncogene homolog 1(GLI1) expression correlates with the clinical significance and prognosis of several cancers. However, the evaluation of the role GLI1 expression plays in pancreatic ductal adenocarcinoma (PDAC) clinicopathological features and outcomes still lacks.
Objective: The present study systemic reviewed the association of GLI1 expression and clinical significance as well as patients survival in PDAC.
Methods: We systematically searched the database of The Cochrane Library, PubMed, Embase, CNKI, Weipu data, and Wanfang data according to the inclusion and exclusion criteria. (The search ended on January 1, 2019; no language restrictions). The Newcastle-Ottawa Scale (NOS) scale was implemented to assess the quality of the literature and the Review Manager 5.3 Software was used to conduct a meta-analysis. Finally, 9 studies, a total of 1058 patients, have been included.
Results: GLI1 is more likely expressed in PDAC tissue rather than para-carcinoma tissue (OR = 2.86, 95%CI = 1.87-4.36, P < .00001). GLI1 expression is associated with the TNM stage (OR = 3.11, 95%CI = 2.01-4.79, P < .00001), perineural invasion (OR = 2.50, 95%CI = 1.28-4.91, P = .008), and lymphatic metastasis (OR = 2.73, 95%CI = 1.71-4.36, P < .0001). But the association with differentiation (OR = 1.20, 95%CI = 0.74-1.96, P = .46) and tumor size (OR = 2.41, 95%CI = 0.97-6.00, P = .06) was not significant. GLI1 expression is related to the worse overall survival in PDACs (HR = 1.68, 95%CI = 1.40-2.02, P < .00001).
Conclusion: Positive GLI1 expression promotes the progression and metastasis of PDACs and plays an important role in the clinical significance and the patients survival.

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