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Tytuł pozycji:

Circulating Matrix Metalloproteinase-28 Levels Are Related to GRACE Scores and Short-Term Outcomes in Patients with Acute Myocardial Infarction.

Tytuł :
Circulating Matrix Metalloproteinase-28 Levels Are Related to GRACE Scores and Short-Term Outcomes in Patients with Acute Myocardial Infarction.
Autorzy :
Zhou K; Nanjing Medical University, Nanjing, Jiangsu 211166, China.; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Li Y; Department of Cardio-Thoracic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Xu Y; Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Guo R; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 May 25; Vol. 2020, pp. 9206703. Date of Electronic Publication: 2020 May 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Observational Study
Język :
English
Imprint Name(s) :
Original Publication: New York, NY : Hindawi Pub. Co.
MeSH Terms :
Myocardial Infarction*/blood
Myocardial Infarction*/diagnosis
Myocardial Infarction*/epidemiology
Myocardial Infarction*/mortality
Matrix Metalloproteinases, Secreted/*blood
Adult ; Aged ; Biomarkers/blood ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Registries ; Retrospective Studies ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/mortality
References :
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Substance Nomenclature :
0 (Biomarkers)
EC 3.4.24.- (Matrix Metalloproteinases, Secreted)
Entry Date(s) :
Date Created: 20200630 Date Completed: 20210330 Latest Revision: 20210330
Update Code :
20210331
PubMed Central ID :
PMC7273487
DOI :
10.1155/2020/9206703
PMID :
32596395
Czasopismo naukowe
Objective: To investigate the relationship between the level of matrix metalloproteinase-28 (MMP-28) in patients with acute myocardial infarction (AMI) and the global registry of acute coronary events (GRACE) scores as well as their short-term prognosis.
Methods: Two hundred eleven patients with AMI were enrolled, and their basic clinical characteristics were collected for determining the GRACE score. We measured the plasma levels of MMP-28 and other biomarkers in the study population. The association of MMP-28 levels with cardiac events and cardiac deaths occurring within 30 days of discharge was evaluated with multivariable Cox proportional hazard models.
Results: The MMP-28 levels were significantly higher in patients with acute ST-elevation myocardial infarction (STEMI) than in patients with non-ST-elevation myocardial infarction (NSTEMI) ( P < 0.01). Correlation analysis showed that the level of MMP-28 was positively correlated with the GRACE score in patients with AMI ( R 2 = 0.366, P < 0.05). Cox multivariate regression results showed that MMP-28 was associated with cardiovascular events during the hospitalization and 30 days after discharge ( P < 0.01). In addition, Kaplan-Meier analysis showed that cardiac events and deaths were significantly higher in patients with MMP-28 ≥ 1.21 ng/mL (all P < 0.01).
Conclusion: There is a correlation between the plasma MMP-28 level and GRACE score in patients with AMI. MMP-28 is also associated with cardiovascular events and cardiovascular deaths during the hospitalization of patients and within 30 days of discharge.
(Copyright © 2020 Ke Zhou et al.)
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