Mitochondrial DNA genomes revealed different patterns of high-altitude adaptation in high-altitude Tajiks compared with Tibetans and Sherpas.

Tytuł:: Mitochondrial DNA genomes revealed different patterns of high-altitude adaptation in high-altitude Tajiks compared with Tibetans and Sherpas.
Autorzy:: Chen Y; Department of Military Medical Geography, Army Health Service Training Base, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Gong L; Department of Military Medical Geography, Army Health Service Training Base, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Liu X; Department of Military Medical Geography, Army Health Service Training Base, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Chen X; Department of Military Medical Geography, Army Health Service Training Base, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yang S; Health Department of the 957th Hospital of PLA, Ali, 859000, Tibet, China. .
Luo Y; Department of Military Medical Geography, Army Health Service Training Base, Third Military Medical University (Army Medical University), Chongqing, 400038, China. .
Źródło:: Scientific reports [Sci Rep] 2020 Jun 29; Vol. 10 (1), pp. 10592. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Adaptation, Physiological/*genetics
Ethnicity/*genetics
Genome, Mitochondrial/*genetics
Altitude ; Altitude Sickness/genetics ; Asia, Central ; Asian People/genetics ; China ; DNA, Mitochondrial/analysis ; DNA, Mitochondrial/genetics ; Asia, Eastern ; Genetics, Population/methods ; Haplotypes/genetics ; Humans ; Mitochondria/genetics ; Sequence Analysis, DNA/methods ; Tibet
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Substance Nomenclature:: 0 (DNA, Mitochondrial)
Entry Date(s):: Date Created: 20200701 Date Completed: 20210115 Latest Revision: 20221207
Update Code:: 20240105
PubMed Central ID:: PMC7324373
DOI:: 10.1038/s41598-020-67519-z
PMID:: 32601317
: Czasopismo naukowe

Pełny tekst

High-altitude Tajiks (HA-Tajiks), Tibetans and Sherpas are three groups of high-altitude native people in China. The differences in the mtDNA genome between the three populations and the role of the mtDNA genome in the high-altitude adaptation of HA-Tajiks were seldom investigated. In this study, 80 HA-Tajiks were enrolled, and their whole mtDNA genomes were sequenced. The haplogroup of each subject was determined by comparison to the revised Cambridge Reference Sequence (rCRS). Ten additional populations from East Asia and Central Asia, including Tibetans and Sherpas, were selected as references. The top haplogroup was U, followed by H, T and J. Principle component analysis and genetic distance analysis indicated that HA-Tajiks showed a close relationship with Wakhi Tajiks, Pamiri Tajiks and Sarikoli Tajiks, indicating that they should be considered one nation scattered around the Pamirs. The difference in the mtDNA genome between HA-Tajiks and Sherpas was significantly greater than that between HA-Tajiks and Tibetans. Among the 13 genes related to the OXPHOS pathway encoded by the mtDNA genome, HA-Tajiks showed more significant differences in ND3 and CYTB compared to Tibetans. Compared to Sherpas, HA-Tajiks showed more significant differences in ND1, ND2, COX1, ATP8, ATP6, ND3, ND4L, ND4, ND5 and CYTB. The associated functional changes and underlying molecular mechanisms should be explored by molecular and biochemical investigations in further studies.

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