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Tytuł pozycji:

A Randomized Comparison Study of Lyophilized Nile Tilapia Skin and Silver-Impregnated Sodium Carboxymethylcellulose for the Treatment of Superficial Partial-Thickness Burns.

Tytuł :
A Randomized Comparison Study of Lyophilized Nile Tilapia Skin and Silver-Impregnated Sodium Carboxymethylcellulose for the Treatment of Superficial Partial-Thickness Burns.
Autorzy :
Lima Júnior EM; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil.
de Moraes Filho MO; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Costa BA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Fechine FV; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Rocha MBS; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Vale ML; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.; Graduate Program in Morphofunctional Sciences, School of Medicine, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Diógenes AKL; Graduate Program in Morphofunctional Sciences, School of Medicine, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Uchôa AMDN; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil.
Silva Júnior FR; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil.
Martins CB; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Bandeira TJPG; School of Medicine, Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Rocha Rodrigues FA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.; Federal Institute of Education, Science and Technology of Ceará (IFCE) - Campus, Jaguaribe, Jaguaribe, CE, Brazil.
Paier CRK; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
de Moraes MEA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
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Źródło :
Journal of burn care & research : official publication of the American Burn Association [J Burn Care Res] 2020 Jun 30. Date of Electronic Publication: 2020 Jun 30.
Publication Model :
Ahead of Print
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 2018- : Oxford : Oxford University Press
Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, c2006-
Contributed Indexing :
Keywords: Oreochromis niloticus; Nile Tilapia; biocompatible materials; burns; xenograft
Entry Date(s) :
Date Created: 20200701 Latest Revision: 20200630
Update Code :
20201218
DOI :
10.1093/jbcr/iraa099
PMID :
32603408
Czasopismo naukowe
Background: Glycerolized Nile tilapia skin showed promising results when used for burn treatment in phase II and phase III randomized controlled trials. This pilot study aims to evaluate the effectiveness of lyophilized Nile tilapia skin as a temporary skin substitute for superficial partial-thickness burns by comparing it to silver-impregnated sodium carboxymethylcellulose dressing.
Methods: This was a randomized, prospective, open-label, controlled pilot study conducted in Fortaleza, Brazil, from April 2019 to December 2019. The 24 participants had ≥18 and ≤70 years of age and superficial partial-thickness burns affecting up to 10% of total body surface area. Primary outcomes were the number of dressings performed and pain intensity, assessed via the Visual Analogue Scale and the Electronic von Frey. Secondary outcomes were the level of pain-related anxiety, assessed via the Burns Specific Pain Anxiety Scale, and analgesic consumption.
Results: In the test group, the number of dressings and the patient-reported pain after dressing-related procedures were lower. Analgesic intake, pain-related anxiety, and both patient-reported and objectively measured pain before dressing-related procedures were similar for the treatment groups. No side effects were detected.
Conclusion: Lyophilized Nile tilapia skin shares the same characteristics of an ''ideal'' wound dressing demonstrated by glycerolized Nile tilapia skin in previous studies. Also, it demonstrated non-inferiority for burn management when compared to silver-impregnated sodium carboxymethylcellulose dressing. The safety and efficacy of lyophilized Nile tilapia skin demonstrated in this pilot study may allow the development of larger phase II and phase III RCTs in a near future.
(© The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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