Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic.

Tytuł:: Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic.
Autorzy:: Kumsa A; Department of Psychiatry, Institute of Health, Jimma University, Jimma, Ethiopia.
Agenagnew L; Department of Psychiatry, Institute of Health, Jimma University, Jimma, Ethiopia.
Alemu B; Department of Psychiatry, Institute of Health, Jimma University, Jimma, Ethiopia.
Girma S; Department of Psychiatry, Institute of Health, Jimma University, Jimma, Ethiopia.
Źródło:: PloS one [PLoS One] 2020 Jul 02; Vol. 15 (7), pp. e0235365. Date of Electronic Publication: 2020 Jul 02 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Parkinson Disease, Secondary*/chemically induced
Parkinson Disease, Secondary*/epidemiology
Akathisia, Drug-Induced/*epidemiology
Antipsychotic Agents/*adverse effects
Schizophrenia/*drug therapy
Substance-Related Disorders/*epidemiology
Adolescent ; Adult ; Aftercare ; Ambulatory Care Facilities ; Antipsychotic Agents/therapeutic use ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Psychiatry ; Schizophrenia/epidemiology ; Young Adult
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Molecular Sequence:: Dryad 10.5061/dryad.1vhhmgqqb
Substance Nomenclature:: 0 (Antipsychotic Agents)
Entry Date(s):: Date Created: 20200703 Date Completed: 20200922 Latest Revision: 20231103
Update Code:: 20240105
PubMed Central ID:: PMC7332066
DOI:: 10.1371/journal.pone.0235365
PMID:: 32614868
: Czasopismo naukowe

Pełny tekst

Objective: To determine the magnitude and factors associated with psychotropic drug-induced parkinsonism and akathisia among mentally ill patients.
Methods: A hospital-based cross-sectional study was conducted with a total of 410 participants attending a follow-up treatment service at Jimma Medical Center, a psychiatry clinic from April to June 2019. Participants were recruited using a systematic random sampling method. Drug-induced parkinsonism and akathisia were assessed using the Extra-pyramidal Symptom Rating Scale. Substance use was assessed using the World Health Organization Alcohol, Smoking, and Substance Involvement Screening Test. Data entry was done using EpiData version 3.1, and analysis done by the Statistical Package for Social Sciences version 22. Statistically, the significant association was declared by adjusted odds ratio, 95% confidence interval, and p-value less than or equal to 0.05.
Results: The mean age of the respondents was 33.3 years (SD ± 8.55). Most of the participants 223 (54.4%) had a diagnosis of schizophrenia. The prevalence of drug-induced parkinsonism was 14.4% (95% CI: 11.0 to 18.0) and it was 12.4% (95% CI: 9.3 to 15.4) for drug-induced akathisia. The result of the final model found out drug-induced parkinsonism was significantly associated with female sex, age, type of antipsychotics, physical illness, and anti-cholinergic medication use. Similarly, female sex, chlorpromazine equivalent doses of 200 to 600 mg, combined treatment of sodium valproate with antipsychotic, and severe khat/Catha edulis use risk level was significantly associated with akathisia.
Conclusion: One of seven patients developed drug-induced parkinsonism and akathisia. Careful patient assessment for drug-induced movement disorders, selection of drugs with minimal side effects, screening patients for physical illness, and psycho-education on substance use should be given top priority.
Competing Interests: The authors have declared that no competing interests exist.

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