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Tytuł pozycji:

SARS-CoV-2 detection, viral load and infectivity over the course of an infection.

Tytuł :
SARS-CoV-2 detection, viral load and infectivity over the course of an infection.
Autorzy :
Walsh KA; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland. Electronic address: .
Jordan K; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Clyne B; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland; Health Research Board Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.
Rohde D; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Drummond L; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Byrne P; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Ahern S; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Carty PG; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
O'Brien KK; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
O'Murchu E; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
O'Neill M; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
Smith SM; Health Research Board Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.
Ryan M; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland; Department of Pharmacology & Therapeutics, Trinity College Dublin, Trinity Health Sciences, James Street, Dublin 8, Ireland.
Harrington P; Health Information and Quality Authority, Smithfield, Dublin 7, Ireland.
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Źródło :
The Journal of infection [J Infect] 2020 Sep; Vol. 81 (3), pp. 357-371. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Systematic Review
Język :
English
Imprint Name(s) :
Publication: Kent, UK : W.B. Saunders
Original Publication: London, New York, Academic Press.
MeSH Terms :
Viral Load*
Betacoronavirus/*pathogenicity
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Adult ; Asymptomatic Infections/epidemiology ; Child ; Coronavirus Infections/epidemiology ; Feces/virology ; Humans ; Limit of Detection ; Pandemics ; Pneumonia, Viral/epidemiology ; RNA, Viral ; Severity of Illness Index ; Sputum/virology ; Time Factors ; Virus Shedding
Contributed Indexing :
Keywords: COVID-19*; Coronavirus*; Infectivity*; RNA*; Review*; SARS-CoV-2*; Viral load*
Substance Nomenclature :
0 (RNA, Viral)
SCR Disease Name :
COVID-19
Entry Date(s) :
Date Created: 20200703 Date Completed: 20200828 Latest Revision: 20200828
Update Code :
20201023
PubMed Central ID :
PMC7323671
DOI :
10.1016/j.jinf.2020.06.067
PMID :
32615199
Czasopismo naukowe
Objectives: To summarise the evidence on the detection pattern and viral load of SARS-CoV-2 over the course of an infection (including any asymptomatic or pre-symptomatic phase), and the duration of infectivity.
Methods: A systematic literature search was undertaken in PubMed, Europe PubMed Central and EMBASE from 30 December 2019 to 12 May 2020.
Results: We identified 113 studies conducted in 17 countries. The evidence from upper respiratory tract samples suggests that the viral load of SARS-CoV-2 peaks around symptom onset or a few days thereafter, and becomes undetectable about two weeks after symptom onset; however, viral loads from sputum samples may be higher, peak later and persist for longer. There is evidence of prolonged virus detection in stool samples, with unclear clinical significance. No study was found that definitively measured the duration of infectivity; however, patients may not be infectious for the entire duration of virus detection, as the presence of viral ribonucleic acid may not represent transmissible live virus.
Conclusion: There is a relatively consistent trajectory of SARS-CoV-2 viral load over the course of COVID-19 from respiratory tract samples, however the duration of infectivity remains uncertain.
(Copyright © 2020. Published by Elsevier Ltd.)

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