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Tytuł pozycji:

Langerhans Cell Histiocytosis Involving Second Cervical Vertebra and the Hypothalamus and Pituitary in an Adult.

Tytuł:
Langerhans Cell Histiocytosis Involving Second Cervical Vertebra and the Hypothalamus and Pituitary in an Adult.
Autorzy:
Yang IC; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
Lee GJ; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
Han MS; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
Lee SK; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
Moon BJ; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea. Electronic address: .
Lee JK; Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.
Źródło:
World neurosurgery [World Neurosurg] 2020 Oct; Vol. 142, pp. 142-146. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji:
Case Reports
Język:
English
Imprint Name(s):
Original Publication: New York : Elsevier
MeSH Terms:
Cervical Vertebrae/*diagnostic imaging
Histiocytosis, Langerhans-Cell/*diagnostic imaging
Hypothalamus/*diagnostic imaging
Pituitary Diseases/*diagnostic imaging
Pituitary Gland/*diagnostic imaging
Adult ; Antimetabolites, Antineoplastic/administration & dosage ; Antineoplastic Agents, Phytogenic/administration & dosage ; Diabetes Insipidus/diagnostic imaging ; Diabetes Insipidus/drug therapy ; Diabetes Insipidus/etiology ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/drug therapy ; Humans ; Hypothalamus/drug effects ; Male ; Pituitary Diseases/drug therapy ; Pituitary Diseases/etiology ; Pituitary Gland/drug effects
Contributed Indexing:
Keywords: Adult; Cervical spine; Diabetes insipidus; Hypothalamus; Langerhans cell histiocytosis; Pituitary
Substance Nomenclature:
0 (Antimetabolites, Antineoplastic)
0 (Antineoplastic Agents, Phytogenic)
Entry Date(s):
Date Created: 20200703 Date Completed: 20210106 Latest Revision: 20210419
Update Code:
20240105
DOI:
10.1016/j.wneu.2020.06.200
PMID:
32615288
Raport
Background: Adult-onset Langerhans cell histiocytosis (LCH) with simultaneous involvement of the high cervical spine and the hypothalamus is rare.
Case Description: We have reported a case of adult-onset LCH in the second cervical vertebra with bony destruction and subsequent diabetes insipidus due to simultaneous involvement of the hypothalamus and pituitary stalk. Magnetic resonance imaging of the hypothalamus and pituitary lesion and immunohistochemistry of the cervical lesion revealed LCH. Posterior fusion of the cervical spine (first, third, and fourth cervical vertebrae) was performed, followed by systemic chemotherapy. The cervical fusion was well maintained, and the patient achieved clinical remission. No new LCH lesion was found during the follow-up of >2 years.
Conclusions: Patients with known LCH of the spine showing new symptoms of diabetes insipidus should be examined for infiltrating lesions of the pituitary stalk or hypothalamus. In cases of severe instability of the spine, surgical treatment should be performed. If multiple and systemic LCH lesions are found, systemic chemotherapy should be administered.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Comment in: World Neurosurg. 2020 Nov;143:587-588. (PMID: 33167123)

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