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Tytuł:
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Toxicological assessment of seven unregulated drinking water Disinfection By-products (DBPs) using the zebrafish embryo bioassay.
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Autorzy:
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Chaves RS; Institute of Environmental Health, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Empresa Portuguesa das Águas Livres, S.A., Direção Laboratórios e de Controlo da Qualidade da Água, Lisbon, Portugal; CIMAR/CIIMAR, LA- Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Portugal.
Guerreiro CS; Institute of Environmental Health, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Laboratory of Nutrition, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Cardoso VV; Empresa Portuguesa das Águas Livres, S.A., Direção Laboratórios e de Controlo da Qualidade da Água, Lisbon, Portugal.
Benoliel MJ; Empresa Portuguesa das Águas Livres, S.A., Direção Laboratórios e de Controlo da Qualidade da Água, Lisbon, Portugal.
Santos MM; CIMAR/CIIMAR, LA- Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Portugal; FCUP - Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal. Electronic address: .
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Źródło:
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The Science of the total environment [Sci Total Environ] 2020 Nov 10; Vol. 742, pp. 140522. Date of Electronic Publication: 2020 Jun 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Drinking Water*
Water Purification*
Disinfectants/*analysis
Water Pollutants, Chemical/*analysis
Animals ; Biological Assay ; Disinfection ; Humans ; Trihalomethanes ; Zebrafish
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Contributed Indexing:
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Keywords: Drinking water; Emerging contaminant; Human health; Risk assessment; Water quality; Water treatment plant
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Substance Nomenclature:
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0 (Disinfectants)
0 (Drinking Water)
0 (Trihalomethanes)
0 (Water Pollutants, Chemical)
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Entry Date(s):
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Date Created: 20200706 Date Completed: 20200910 Latest Revision: 20200910
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Update Code:
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20240105
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DOI:
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10.1016/j.scitotenv.2020.140522
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PMID:
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32623170
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Disinfection By-products (DBPs) are formed during the chemical treatment of water for human consumption, by the reaction of raw water with chemical agents used in the different steps of the process. Disinfection is one of the most important steps, inactivating pathogens and preventing their regrowth during water distribution. However, it is also involved in DBPs formation due to the use of disinfectant agents, such as chlorine, which reacts with dissolved precursors, such as pharmaceuticals, toxins, pesticides, among others. Given their widespread occurrence, potential human health and (eco) toxicological impacts are of particular interest due to their potential carcinogenicity and various non-carcinogenic effects, such as endocrine disruption. In this study, the developmental toxicity of chemically- different unregulated DBPs was evaluated using zebrafish embryo bioassay. Embryos were exposed to different concentrations of the target DBPs and multiple endpoints, including, mortality, morphological abnormalities and locomotor behavior were assessed at specific developmental stages (24, 48, 72 and 96 hpf). The different families of DBPs tested included nitrosamines, aldehydes, alcohols and ketones. The results show that the effects were compound dependent, with EC10 values varying between 0.04 mg/L (2-ethyl-1-hexanal) to 9.2 mg/L (hexachloroacetone). Globally, several of the tested unregulated DBPs displayed higher toxicity when compared with the available data for some already regulated, such as trihalomethanes (THMs), which highlights the importance of screening the toxicity of still untested and poorly characterized DBPs.
Competing Interests: Declaration of competing interest No conflict of interest.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
