Polygenic prediction of the risk of perinatal depressive symptoms.

Tytuł:: Polygenic prediction of the risk of perinatal depressive symptoms.
Autorzy:: Rantalainen V; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Binder EB; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Lahti-Pulkkinen M; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Pulic Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland.; University/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Czamara D; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Laivuori H; Department of Obstetrics and Gynecology, EBCOG Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland.; Department of Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Institute for Molecular Medicine, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Villa PM; Department of Obstetrics and Gynaecology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Girchenko P; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kvist T; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Hämäläinen E; Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland.
Kajantie E; Pulic Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland.
Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, Helsinki, Finland.
Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Źródło:: Depression and anxiety [Depress Anxiety] 2020 Sep; Vol. 37 (9), pp. 862-875. Date of Electronic Publication: 2020 Jul 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: New York, NY : Wiley, c1997-
MeSH Terms:: Bipolar Disorder*/epidemiology
Bipolar Disorder*/genetics
Depression, Postpartum*/epidemiology
Depression, Postpartum*/genetics
Depressive Disorder, Major*/epidemiology
Depressive Disorder, Major*/genetics
Pregnancy Complications*/epidemiology
Pregnancy Complications*/genetics
Child ; Depression ; Female ; Humans ; Multifactorial Inheritance/genetics ; Pregnancy ; Prospective Studies ; Risk Factors
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Grant Information:: International Foundation of Pediatric Research; 724363 for PremLife International European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL); International Academy of Finland; International Juho Vainio Foundation; International Signe ja Ane Gyllenbergin Säätiö; International Novo Nordisk Foundation; International Sigrid Juselius Foundation; Horizon 2020 Award SC1-2016-RTD-733280 RECAP International European Commission
Contributed Indexing:: Keywords: depression; epidemiology; genetics; mood disorders; pregnancy and postpartum
Entry Date(s):: Date Created: 20200707 Date Completed: 20201231 Latest Revision: 20201231
Update Code:: 20240105
DOI:: 10.1002/da.23066
PMID:: 32627298
: Czasopismo naukowe

Pełny tekst

Background: Perinatal depression carries adverse effects on maternal health and child development, but genetic underpinnings remain unclear. We investigated the polygenic risk of perinatal depressive symptoms.
Methods: About 742 women from the prospective Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction cohort were genotyped and completed the Center for Epidemiologic Studies Depression scale 14 times during the prenatal period and twice up to 12 months postpartum. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and cross-disorder were calculated using multiple p-value thresholds.
Results: Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder, but not bipolar disorder, were associated with higher prenatal and postpartum depressive symptoms (0.8%-1% increase per one standard deviation increase in polygenic risk scores). Prenatal depressive symptoms accounted for and mediated the associations between the polygenic risk scores and postpartum depressive symptoms (effect size proportions-mediated: 52.2%-88.0%). Further, the polygenic risk scores were associated with 1.24-1.45-fold odds to belong to the group displaying consistently high compared with consistently low depressive symptoms through out the prenatal and postpartum periods.
Conclusions: Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder in non-perinatal populations generalize to perinatal depressive symptoms and may afford to identify women for timely preventive interventions.
(© 2020 The Authors. Depression and Anxiety published by Wiley Periodicals LLC.)

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