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Tytuł pozycji:

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.

Tytuł:
Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.
Autorzy:
Erbaba B; Interdisciplinary Graduate Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; UNAM - National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Turkey.
Burhan ÖP; Interdisciplinary Graduate Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; UNAM - National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Turkey.
Şerifoğlu N; Interdisciplinary Graduate Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; UNAM - National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Turkey; Stem Cell Research and Application Center, Hacettepe University, Ankara, Turkey.
Muratoğlu B; Stem Cell Research and Application Center, Hacettepe University, Ankara, Turkey.
Kahveci F; Department of Computer Engineering, Bilkent University, Ankara, Turkey.
Adams MM; Interdisciplinary Graduate Program in Neuroscience, Aysel Sabuncu Brain Research Center, Bilkent University, Ankara, Turkey; UNAM - National Nanotechnology Research Center and Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, Turkey; Department of Molecular Biology and Genetics Zebrafish Facility, Bilkent University, Ankara, Turkey; Department of Psychology, Bilkent University, Ankara, Turkey; UMRAM, National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey.
Arslan-Ergül A; Stem Cell Research and Application Center, Hacettepe University, Ankara, Turkey. Electronic address: .
Źródło:
Neurobiology of aging [Neurobiol Aging] 2020 Oct; Vol. 94, pp. 164-175. Date of Electronic Publication: 2020 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
MeSH Terms:
Aging/*genetics
Aging/*metabolism
Brain/*metabolism
Cell Adhesion Molecules/*genetics
Cell Adhesion Molecules/*metabolism
RNA/*genetics
RNA/*metabolism
Sequence Analysis, RNA/*methods
Activated-Leukocyte Cell Adhesion Molecule/genetics ; Activated-Leukocyte Cell Adhesion Molecule/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Cell Adhesion Molecules, Neuronal/genetics ; Cell Adhesion Molecules, Neuronal/metabolism ; Connexins/genetics ; Fetal Proteins/genetics ; Fetal Proteins/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Developmental/genetics ; Humans ; Zebrafish
Contributed Indexing:
Keywords: Brain aging; Cell adhesion molecules; RNA sequencing; Zebrafish
Substance Nomenclature:
0 (ALCAM protein, human)
0 (Activated-Leukocyte Cell Adhesion Molecule)
0 (Antigens, CD)
0 (Cell Adhesion Molecules)
0 (Cell Adhesion Molecules, Neuronal)
0 (Connexins)
0 (Fetal Proteins)
0 (connexin 47)
63231-63-0 (RNA)
Entry Date(s):
Date Created: 20200707 Date Completed: 20210629 Latest Revision: 20210629
Update Code:
20240105
DOI:
10.1016/j.neurobiolaging.2020.04.017
PMID:
32629311
Czasopismo naukowe
Brain aging is a complex process, which involves multiple pathways including various components from cellular to molecular. This study aimed to investigate the gene expression changes in zebrafish brains through young-adult to adult, and adult to old age. RNA sequencing was performed on isolated neuronal cells from zebrafish brains. The cells were enriched in progenitor cell markers, which are known to diminish throughout the aging process. We found 176 statistically significant, differentially expressed genes among the groups, and identified a group of genes based on gene ontology descriptions, which were classified as cell adhesion molecules. The relevance of these genes was further tested in another set of zebrafish brains, human healthy, and Alzheimer's disease brain samples, as well as in Allen Brain Atlas data. We observed that the expression change of 2 genes, GJC2 and ALCAM, during the aging process was consistent in all experimental sets. Our findings provide a new set of markers for healthy brain aging and suggest new targets for therapeutic approaches to neurodegenerative diseases.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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