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Tytuł:
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Comparison of the detection rate of cervical lesion with TruScreen, LBC test and HPV test: A Real-world study based on population screening of cervical cancer in rural areas of China.
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Autorzy:
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Ma Y; National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Di J; National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Bi H; Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Zhao Q; Department of Gynecology, Sichuan Provincial Hospital for Women and Children, Chengdu, China.
Qin T; Department of Gynecological Clinic, Xinjiang Uygur Autonomous Region Maternal and Child Health Hospital, Ürümqi, China.
Xu W; Women's Health Care Department, Haidian Maternal and Child Health Hospital, Beijing, China.
Liu Z; Department of Gynecology, Northwest Women's and Children's Hospital (Shaanxi Maternal and Child Health Hospital), Xi'an, China.
Yi N; Department of Women's Health Care, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
Zhao J; Department of Gynecology, Hunan Provincial Maternal and Child Health Hospital, Changsha, China.
Zhou D; Cervical Disease Treatment Center, Chongqing Health Center for Women and Children, Chongqing, China.
Chen J; Cervical Disease Diagnosis and Treatment Health Center, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yang Q; National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China.
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Źródło:
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PloS one [PLoS One] 2020 Jul 07; Vol. 15 (7), pp. e0233986. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).
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Typ publikacji:
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Comparative Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Early Detection of Cancer/*methods
Papillomavirus Infections/*diagnosis
Uterine Cervical Neoplasms/*diagnosis
Uterine Cervical Dysplasia/*diagnosis
Adult ; Alphapapillomavirus ; China/epidemiology ; Colposcopy ; Early Detection of Cancer/statistics & numerical data ; Female ; Geography, Medical ; Humans ; Middle Aged ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/pathology ; Prevalence ; Program Evaluation ; Rural Population ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology ; Vaginal Smears/methods ; Uterine Cervical Dysplasia/epidemiology ; Uterine Cervical Dysplasia/pathology
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References:
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Entry Date(s):
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Date Created: 20200708 Date Completed: 20200908 Latest Revision: 20240329
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Update Code:
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20240329
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PubMed Central ID:
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PMC7340311
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DOI:
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10.1371/journal.pone.0233986
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PMID:
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32634143
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Background and Objective: China carries a heavy burden of cervical cancer and has an alarmingly low cervical cancer screening rate. In order to achieve the goal of cervical cancer elimination, there is an urgent need for suitable methods and strategies in China.
Materials and Methods: A total 9972 woman who received cervical cancer screening services of National Cervical Cancer Screening Program in Rural Areas (NCCSPRA) in 8 project counties participated in this study. TruScreen, HPV test and LBC test were performed in all participants. A total of 1945women had one or more than one positive or abnormal screening results of the above three screening tests subsequently received colposcopy. The detection rate of CIN2+ between the three tests were compared.
Results: No matter what kind of screening method is used, the CIN2+ detection rate in the eastern regions was much higher than that in the central and western regions. The total detection rate of CIN2+ in HPV group was highest (0.73%), following in LBC group (0.44%) and TS group (0.31%). There was statistically significant difference in the total detection rate of CIN2+ between TS and HPV groups, LBC and HPV groups, respectively. There was no statistical difference in the total detection rate of CIN2+ between TS and LBC screening groups. Moreover, except for the eastern regions, there was no statistical difference in the detection rate of CIN2+ between TS group and the other two groups in central and western regions.
Conclusion: If it can meet the requirements of the laboratory and personnel, HPV test seems to be the preferred method for cervical cancer screening in rural areas of China. The characteristics of minimal training requirements, simple operation, real-time results obtained without the collection of cervical cell samples and the help of laboratory equipment and cytologists of TS make it ideal for cervical cancer screening in low-resource regions.
Competing Interests: The authors have declared that no competing interests exist.
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