Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.

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Tytuł:: Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.
Autorzy:: Torabi R; Laboratory of Bioanalysis, Institute of Biochemistry & Biophysics, Tehran University, Tehran, Iran.
Ranjbar R; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Halaji M; Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Heiat M; Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: .
Źródło:: Molecular and cellular probes [Mol Cell Probes] 2020 Oct; Vol. 53, pp. 101636. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji:: Journal Article; Meta-Analysis; Systematic Review
Język:: English
Imprint Name(s):: Original Publication: London ; New York : Academic Press, c1987-
MeSH Terms:: Biosensing Techniques*
Antiviral Agents/*therapeutic use
Aptamers, Nucleotide/*therapeutic use
Coronavirus Infections/*diagnosis
Coronavirus Infections/*drug therapy
Antiviral Agents/metabolism ; Aptamers, Nucleotide/metabolism ; COVID-19 ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy
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Contributed Indexing:: Keywords: Aptamer; COVID-19; Coronavirus; MERS; Probe; SARS; SARS-CoV-2; Therapy
Substance Nomenclature:: 0 (Antiviral Agents)
0 (Aptamers, Nucleotide)
Entry Date(s):: Date Created: 20200708 Date Completed: 20200929 Latest Revision: 20230306
Update Code:: 20240105
PubMed Central ID:: PMC7334654
DOI:: 10.1016/j.mcp.2020.101636
PMID:: 32634550
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The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)

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