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Tytuł pozycji:

Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism.

Tytuł:
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism.
Autorzy:
Hansen ES; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Hindberg K; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Latysheva N; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Aukrust P; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, and.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; and.
Ueland T; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, and.
Hansen JB; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Brækkan SK; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.; Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Morelli VM; K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.
Corporate Authors:
INVENT Consortium
Źródło:
Blood [Blood] 2020 Oct 15; Vol. 136 (16), pp. 1863-1870.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2021- : [New York] : Elsevier
Original Publication: New York, Grune & Stratton [etc.]
MeSH Terms:
Disease Susceptibility*
Biomarkers/*blood
Growth Differentiation Factor 15/*blood
Venous Thromboembolism/*blood
Venous Thromboembolism/*etiology
Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Growth Differentiation Factor 15/genetics ; Humans ; Male ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prognosis ; Risk Assessment ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology
Substance Nomenclature:
0 (Biomarkers)
0 (GDF15 protein, human)
0 (Growth Differentiation Factor 15)
Entry Date(s):
Date Created: 20200710 Date Completed: 20210614 Latest Revision: 20210614
Update Code:
20240105
DOI:
10.1182/blood.2019004572
PMID:
32645137
Czasopismo naukowe
Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association using Mendelian randomization (MR). We conducted a population-based nested case-control study comprising 416 VTE patients and 848 age- and sex-matched controls derived from the Tromsø Study. Logistic regression was used to calculate odds ratios (ORs) for VTE across GDF-15 quartiles. For the MR, we used data from the International Network on Venous Thrombosis (INVENT) consortium to examine whether single nucleotide polymorphisms (SNPs) associated with GDF-15 levels with genome-wide significance were related to VTE. We found that the ORs for VTE increased across GDF-15 quartiles (Ptrend = .002). Participants with GDF-15 values in the highest quartile (≥358 pg/mL) had an OR for VTE of 2.05 (95% confidence interval, 1.37-3.08) compared with those with GDF-15 in the lowest quartile (<200 pg/mL) in the age- and sex-adjusted model. ORs remained essentially the same after further adjustment for body mass index, smoking, hormone therapy, physical activity, and C-reactive protein. Similar results were obtained for provoked/unprovoked events, deep vein thrombosis, and pulmonary embolism. GDF-15 levels, as predicted by the SNPs, were not associated with VTE in MR. Our results indicate that high GDF-15 levels are associated with increased risk of VTE, but MR suggests that this association is not causal.
(© 2020 by The American Society of Hematology.)

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