-
Tytuł:
-
Design and Synthesis of an Aniline Derivative with Biological Activity on Heart Failure.
-
Autorzy:
-
Alejandra GE; Facultad de Medicina, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz, Mexico.
Lauro FV; Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Campeche, Mexico.
Marcela RN; Facultad de Nutricion, Universidad Veracruzana. Medicos y Odontologos s/n, 91010, Xalapa, Veracruz, Mexico.
Maria LR; Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Campeche, Mexico.
Francisco DC; Escuela Nacional de Ciencias Biologicas del Instituto Politecnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, Mexico.
Virginia MA; Facultad de Nutricion, Universidad Veracruzana. Medicos y Odontologos s/n, 91010, Xalapa, Veracruz, Mexico.
Yazmin OA; Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kala s/n, 24085 San Francisco de Campeche, Campeche, Mexico.
-
Źródło:
-
Combinatorial chemistry & high throughput screening [Comb Chem High Throughput Screen] 2021; Vol. 24 (2), pp. 220-232.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers
Original Publication: Hilversum, Netherlands ; Miami, FL : Bentham Science Publishers, c1998-
-
MeSH Terms:
-
Drug Design*
Aniline Compounds/*therapeutic use
Heart Failure/*drug therapy
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Animals ; Male ; Molecular Structure ; Rats ; Rats, Wistar
-
Contributed Indexing:
-
Keywords: Synthesis; aniline; biological activity; derivatives; etherification; heart failure
-
Substance Nomenclature:
-
0 (Aniline Compounds)
-
Entry Date(s):
-
Date Created: 20200711 Date Completed: 20210914 Latest Revision: 20210914
-
Update Code:
-
20240105
-
DOI:
-
10.2174/1386207323666200709163008
-
PMID:
-
32646352
-
Background: Several compounds have been synthesized as a therapeutic alternative for heart failure; however, its preparation requires special conditions.
Objective: The aim of this study, was to synthesize some aniline derivatives (4-9) from 3- ethynylaniline to evaluate their biological activity against heart failure.
Methods: The synthesis of aniline derivatives involved a series of reactions such as etherification, addition, and cyclization. The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods. In addition, to evaluate the biological activity of compounds, an ischemia/reperfusion injury model was used.
Results: The results showed that compound 8 decreases heart failure, which translates into a decrease in the infarction area compared to compounds 4-7 and 9.
Conclusion: This study reports a facile method for the preparation of aniline derivatives. This method offers some advantages such as; a simple procedure, low cost, and easy work up. In addition, compound 8 showed an interesting biological activity against heart failure. This phenomenon is particularly interesting because the biological activity induced by this compound could involve a molecular mechanism that is different from other drugs used for the treatment of heart failure.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
