Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors.

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Abstrakt

Tytuł:: Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors.
Autorzy:: Liguoro I; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.
Passone E; Division of Pediatrics, University Hospital of Udine, Udine, Italy.
Zilli T; San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.
Maieron M; Department of Medical Physics, University Hospital of Udine, Udine, Italy.
De Colle MC; Department of Neuroradiology, University Hospital of Udine, Udine, Italy.
Skrap M; Department of Neurosurgery, University Hospital of Udine, Udine, Italy.
Dolcemascolo V; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.
Sommariva G; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.; Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Cogo P; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.; Division of Pediatrics, University Hospital of Udine, Udine, Italy.
Tomasino B; San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.
Źródło:: Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Sep; Vol. 67 (9), pp. e28538. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Hoboken, N.J. : John Wiley, c 2004-
MeSH Terms:: Cerebellar Neoplasms/*surgery
Cognition Disorders/*pathology
Infratentorial Neoplasms/*surgery
Medulloblastoma/*surgery
Memory Disorders/*pathology
Neurosurgical Procedures/*adverse effects
Adolescent ; Cerebellar Neoplasms/pathology ; Child ; Child, Preschool ; Cognition Disorders/etiology ; Diffusion Tensor Imaging ; Female ; Follow-Up Studies ; Humans ; Infratentorial Neoplasms/pathology ; Intelligence Tests ; Male ; Medulloblastoma/pathology ; Memory Disorders/etiology ; Neuroimaging ; Neuropsychological Tests ; Pilot Projects ; Prognosis ; Retrospective Studies
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Contributed Indexing:: Keywords: brain tumors; neuro-oncology; psychosocial
Entry Date(s):: Date Created: 20200712 Date Completed: 20201207 Latest Revision: 20201214
Update Code:: 20240105
DOI:: 10.1002/pbc.28538
PMID:: 32652734
: Czasopismo naukowe

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Background: Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro-cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)-based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long-term follow-up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning.
Methods: DTI-based tractography was performed in pediatric patients with PF tumors. Fractional anisotropy (FA) and volumetric measurements of spinocerebellar, dentorubrothalamocortical and corticopontocerebellar tracts were analyzed. Cognitive and neuropsychological functioning was assessed by the Wechsler Intelligence Scale for Children-IV Edition (WISC-IV) and the Developmental Neuropsychological Assessment (NEPSY II). The associations between Full-Scale Intelligence Quotient (FSIQ), NEPSY-II scores, and fiber tracts were tested by the Spearman rank correlation coefficient.
Results: Seven patients (median age at diagnosis five years, range, 3-13) treated for medulloblastoma (2/7; 29%) and pilocytic astrocytoma (5/7; 71%) were retrospectively evaluated. All children had complete surgery. The median FSIQ was 84 (range, 67-93). Patients presented with several deficits on many NEPSY-II tasks; in particular, memory was impaired in nearly half of them. FSIQ and neurocognitive tasks significantly correlated with specific corticopontocerebellar tracts.
Conclusion: Children on follow-up for PF tumor showed scattered cognitive impairments, including deficits in long-term and immediate memory. Tractography allowed us to describe a possible association between the integrity of cerebellar pathways and neurocognitive performance, suggesting that the myelinization of these fibers may represent an indicator for the development of long-term cognitive sequelae.
(© 2020 Wiley Periodicals LLC.)

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