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Tytuł:
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H NMR-based metabonomic evaluation of the pesticides camptothecin and matrine against larvae of Spodoptera litura.
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Autorzy:
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Dai LS; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Tian HF; School of Stomatology, Wenzhou Medical University, Wenzhou, China.
Hang Y; Biotechnology Center of Anhui Agricultural University, Anhui Agricultural University, Hefei, China.
Wen CW; School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Huang YH; Renji College, Wenzhou Medical University, Wenzhou, China.
Wang BF; School of Stomatology, Wenzhou Medical University, Wenzhou, China.
Hu JW; Biotechnology Center of Anhui Agricultural University, Anhui Agricultural University, Hefei, China.
Xu JP; School of Life Sciences, Anhui Agricultural University, Hefei, China.
Deng MJ; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
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Źródło:
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Pest management science [Pest Manag Sci] 2021 Jan; Vol. 77 (1), pp. 208-216. Date of Electronic Publication: 2020 Aug 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: West Sussex, UK : Published for SCI by Wiley, c2000-
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MeSH Terms:
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Pesticides*
Alkaloids ; Animals ; Camptothecin/toxicity ; Larva ; Quinolizines ; Spodoptera ; Matrines
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References:
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Grant Information:
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LY20C040002 Natural Science Foundation of Zhejiang Province
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Contributed Indexing:
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Keywords: Spodoptera litura; camptothecin; matrine; metabonomics; toxicity
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Substance Nomenclature:
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0 (Alkaloids)
0 (Pesticides)
0 (Quinolizines)
XT3Z54Z28A (Camptothecin)
0 (Matrines)
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Entry Date(s):
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Date Created: 20200718 Date Completed: 20201221 Latest Revision: 20221207
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Update Code:
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20240105
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DOI:
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10.1002/ps.6009
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PMID:
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32677739
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Background: Camptothecin (CPT) and matrine (MAT) have potential as botanical pesticides against several pest species. However, the mechanisms of metabolic and physiological changes in pests induced by CPT and MAT are unknown. In this study, a toxicological test, an NMR-based metabolomic study, an enzymatic test, and an RT quantitative PCR (RT-qPCR) experiment were all conducted to examine the effect of CPT and MAT on Spodoptera litura.
Results: CPT (0.5-1%) exerted high toxicity against larvae of S. litura and caused growth stagnation and high mortality of larvae. A variety of metabolites were significantly influenced by 0.5% CPT, including several energy-related metabolites such as trehalose, lactate, succinate, citrate, malate, and fumarate. In contrast, MAT showed low toxicity against larvae and induced almost no changes in hemolymph metabolites of S. litura. Enzymatic tests showed that trehalase activity was significantly decreased in larvae after feeding with 0.5% CPT. RT-qPCR showed that the transcription levels of alanine aminotransferase, malate dehydrogenase, and isocitrate dehydrogenase were decreased while lactate dehydrogenase was increased in the 0.5% CPT-treated group.
Conclusions: These data indicate that one of the important mechanisms of CPT against S. litura larvae is via the inhibition of trehalose hydrolysis and glycolysis. Our findings also suggest that CPT exhibits a stronger toxicological effect than MAT against S. litura, which provides basic information for the application of CPT in the control of S. litura or other lepidoptera pests.
(© 2020 Society of Chemical Industry.)