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Tytuł pozycji:

A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.

Tytuł :
A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.
Autorzy :
Zeng M; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Li M; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Chen Y; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Zhang J; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Cao Y; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Zhang B; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Feng W; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.
Zheng X; Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: .
Yu Z; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: .
Pokaż więcej
Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Sep 15; Vol. 690, pp. 108506. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: <2000- > : San Diego, CA : Elsevier
Original Publication: New York, NY : Academic Press
MeSH Terms :
Chrysanthemum/*chemistry
Flowers/*chemistry
Inflammation Mediators/*metabolism
Plant Extracts/*chemistry
Polyynes/*chemistry
Toll-Like Receptor 4/*metabolism
Animals ; Cytokines/chemistry ; Drug Discovery ; Humans ; Inflammation/metabolism ; Lipopolysaccharides/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Myocytes, Cardiac/metabolism ; Polyynes/pharmacology ; Signal Transduction ; Structure-Activity Relationship
Contributed Indexing :
Keywords: Bisepoxylignan*; Cardiomyocyte*; Dendranlignan A*; Structural elucidation*; TLR4*
Substance Nomenclature :
0 (Cytokines)
0 (Inflammation Mediators)
0 (Lipopolysaccharides)
0 (Plant Extracts)
0 (Toll-Like Receptor 4)
0 (dendrazawayne A)
25067-58-7 (Polyynes)
Entry Date(s) :
Date Created: 20200718 Date Completed: 20200930 Latest Revision: 20200930
Update Code :
20201023
DOI :
10.1016/j.abb.2020.108506
PMID :
32679197
Czasopismo naukowe
A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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