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Tytuł pozycji:

Supplemental effects of dietary lysophospholipids in lactation diets on sow performance, milk composition, gut health, and gut-associated microbiome of offspring.

Tytuł:
Supplemental effects of dietary lysophospholipids in lactation diets on sow performance, milk composition, gut health, and gut-associated microbiome of offspring.
Autorzy:
Jang KB; Department of Animal Science, North Carolina State University, Raleigh, NC.
Purvis JM; N.G. Purvis Farm Inc., Robbins, NC.
Kim SW; Department of Animal Science, North Carolina State University, Raleigh, NC.
Źródło:
Journal of animal science [J Anim Sci] 2020 Aug 01; Vol. 98 (8).
Typ publikacji:
Journal Article; Randomized Controlled Trial, Veterinary
Język:
English
Imprint Name(s):
Original Publication: Champaign, IL : American Society of Animal Science
MeSH Terms:
Dietary Supplements*
Gastrointestinal Microbiome*
Animal Feed/*analysis
Lysophospholipids/*pharmacology
Milk/*chemistry
Swine/*physiology
Animals ; Body Fluids ; Colostrum/metabolism ; Diet/veterinary ; Fatty Acids, Omega-3/pharmacology ; Female ; Lactation/drug effects ; Litter Size/drug effects ; Lysophospholipids/administration & dosage ; Maternal Nutritional Physiological Phenomena ; Milk/metabolism ; Parity ; Pregnancy
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Contributed Indexing:
Keywords: intestinal health; lactating sow; lysophospholipids; microbiome; milk
Substance Nomenclature:
0 (Fatty Acids, Omega-3)
0 (Lysophospholipids)
Entry Date(s):
Date Created: 20200719 Date Completed: 20201112 Latest Revision: 20210719
Update Code:
20240105
PubMed Central ID:
PMC7457969
DOI:
10.1093/jas/skaa227
PMID:
32681642
Czasopismo naukowe
Dietary lysophospholipids (LPL) would influence milk composition of sows, thus positively affect intestinal health of offspring. The objective of this study was to determine effects of dietary LPL fed to lactating sows on performance, milk characteristics, gut health, and gut-associated microbiome of offspring. Sixty pregnant sows were allotted to 2 treatments in a randomized complete block design with parity and BW as blocks on day 110 of gestation. Treatments were CON (no added LPL) and LPL (0.05% LPL; Lipidol-Ultra, Pathway Intermediates, Shrewsbury, UK). Sows were fed 2 kg/d from day 110 of gestation until farrowing and ad libitum after farrowing. Diets were formulated to meet NRC requirement for lactating sows. Colostrum and milk samples from 12 sows per treatment were collected to measure nutrients and immunoglobulins on days 1 and 18 of lactation, respectively. Twelve piglets per treatment (1 piglet per litter) were euthanized on day 18 to collect tissues to measure tumor necrosis factor-α, interleukin-8 (IL-8), malondialdehyde, protein carbonyl, IgA, histomorphology, crypt cell proliferation rate, and microbiota in the jejunum and colon. Data were analyzed using the MIXED procedure of SAS, and the mortality was analyzed using the GLIMMIX procedure of SAS. There was no difference in sow BW, parity, and litter size between treatments on day 0 of lactation. Sows fed LPL had increased (P < 0.05) litter BW gain (53.9 vs. 59.4 kg) and decreased piglet mortality (13.9% vs. 10.6%) on day 18 of lactation. Sows fed LPL had increased (P < 0.05) omega-6:omega-3 (22.1 vs. 23.7) and unsaturated:saturated (1.4 vs. 1.6) fatty acids ratios with increased oleic acid (29.1% vs. 31.4%) and tended to have increased (P = 0.092) IgG (1.14 vs. 1.94 g/L) and linoleic acid (17.7% vs. 18.7%) in the milk on day 18 of lactation. Piglets from sows fed LPL had increased (P < 0.05) IL-8 (184 vs. 245 pg/mg) and crypt cell proliferation rate (39.4% vs. 40.9%) and tended to have increased (P = 0.095) Firmicutes:Bacteroidetes ratio (1.0 vs. 3.5) in the jejunum. In conclusion, sows fed with LPL had milk with increased IgG, oleic acids, and linoleic acids without changes in BW and backfat during lactation. These changes could contribute to improved survivability and intestinal health of piglets by increasing IL-8 concentration, enhancing balance among gut-associated microbiome, and increasing enterocyte proliferation in the jejunum.
(© The Author(s) 2020. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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