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Tytuł:
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Developmental origins of cardiometabolic health outcomes in twins: A systematic review and meta-analysis.
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Autorzy:
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Ashtree DN; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Parkville, Australia; Twins Research Australia, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Parkville, Australia. Electronic address: .
McGuinness AJ; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.
Plummer M; Adelaide Medical School, Robinson Research Institute, University of Adelaide, Australia.
Sun C; Murdoch Children's Research Institute, Parkville, Australia.
Craig JM; Murdoch Children's Research Institute, Parkville, Australia; Centre for Molecular and Medical Research, School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Australia.
Scurrah KJ; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Parkville, Australia; Twins Research Australia, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Parkville, Australia.
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Źródło:
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Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2020 Sep 24; Vol. 30 (10), pp. 1609-1621. Date of Electronic Publication: 2020 Jun 23.
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Typ publikacji:
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Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: 2005- : Amsterdam : Elsevier
Original Publication: [Heidelberg] : Springer International, c1991-
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MeSH Terms:
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Twins*
Cardiovascular Diseases/*etiology
Diseases in Twins/*etiology
Metabolic Diseases/*etiology
Adiposity ; Adolescent ; Adult ; Aged ; Biomarkers/blood ; Birth Weight ; Blood Glucose/metabolism ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/physiopathology ; Child ; Child, Preschool ; Cholesterol/blood ; Diseases in Twins/blood ; Diseases in Twins/genetics ; Diseases in Twins/physiopathology ; Female ; Gestational Age ; Health Status ; Humans ; Insulin/blood ; Male ; Metabolic Diseases/blood ; Metabolic Diseases/genetics ; Metabolic Diseases/physiopathology ; Middle Aged ; Observational Studies as Topic ; Risk Factors ; Twin Studies as Topic ; Young Adult
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Contributed Indexing:
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Keywords: Cardiometabolic health; DOHaD; Developmental origins of health and disease; Gestational age; Meta-analysis; Systematic review; Twins
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Substance Nomenclature:
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0 (Biomarkers)
0 (Blood Glucose)
0 (Insulin)
97C5T2UQ7J (Cholesterol)
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Entry Date(s):
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Date Created: 20200720 Date Completed: 20201110 Latest Revision: 20201110
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Update Code:
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20240105
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DOI:
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10.1016/j.numecd.2020.06.010
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PMID:
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32682747
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Background and Aims: Studies of twins can reduce confounding and provide additional evidence about the causes of disease, due to within-pair matching for measured and unmeasured factors. Although findings from twin studies are typically applicable to the general population, few studies have taken full advantage of the twin design to explore the developmental origins of cardiometabolic health outcomes. We aimed to systematically review the evidence from twin studies and generate pooled estimates for the effects of early-life risk factors on later-life cardiometabolic health.
Methods and Results: An initial search was conducted in March 2018, with 55 studies of twins included in the review. Risk of bias was assessed using the Newcastle-Ottawa Scale, and eligible studies were included in a meta-analysis, where pooled estimates were calculated. Twenty-six studies analysed twins as individuals, and found that higher birthweight was associated with lower SBP (β = -2.02 mmHg, 95%CI: -3.07, -0.97), higher BMI (β = 0.52 kg/m 2 , 95%CI: 0.20, 0.84) and lower total cholesterol (β = -0.07 mmol/L, 95%CI: -0.11, -0.04). However, no associations were reported in studies which adjusted for gestational age. Few of the included studies separated their analyses into within-pair and between-pair associations.
Conclusions: Early-life risk factors were associated with cardiometabolic health outcomes in twin studies. However, many estimates from studies in this review were likely to have been confounded by gestational age, and few fully exploited the twin design to assess the developmental origins of cardiometabolic health outcomes.
Competing Interests: Declaration of Competing Interest None declared.
(Copyright © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
