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Tytuł:
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A multi-institutional randomized phase III trial comparing anatomical segmentectomy and wedge resection for clinical stage IA non-small cell lung cancer in high-risk operable patients: Japan Clinical Oncology Group Study JCOG1909 (ANSWER study).
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Autorzy:
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Shimoyama R; JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan.
Tsutani Y; Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan.
Wakabayashi M; JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan.
Katayama H; JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan.
Fukuda H; JCOG Data Center/Operations Office, National Cancer Center Hospital, Tokyo, Japan.
Suzuki K; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Watanabe SI; Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
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Corporate Authors:
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Lung Cancer Surgical Study Group
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Źródło:
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Japanese journal of clinical oncology [Jpn J Clin Oncol] 2020 Sep 28; Vol. 50 (10), pp. 1209-1213.
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Typ publikacji:
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Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
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Język:
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English
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Imprint Name(s):
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Publication: Oxford : Oxford University Press
Original Publication: Tokyo, Foundation of Clinical Oncology.
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MeSH Terms:
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Medical Oncology*
Carcinoma, Non-Small-Cell Lung/*pathology
Carcinoma, Non-Small-Cell Lung/*surgery
Lung Neoplasms/*pathology
Lung Neoplasms/*surgery
Aged ; Female ; Follow-Up Studies ; Humans ; Japan ; Male ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Pneumonectomy/adverse effects ; Risk Factors
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Contributed Indexing:
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Keywords: non-small cell lung cancer; randomized controlled trial; segmentectomy; wedge resection
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Entry Date(s):
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Date Created: 20200721 Date Completed: 20201106 Latest Revision: 20210708
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Update Code:
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20240104
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DOI:
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10.1093/jjco/hyaa107
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PMID:
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32687185
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Anatomical segmentectomy or wedge resection is recommended for high-risk operable patients with clinical stage IA non-small cell lung cancer in guidelines of the National Comprehensive Cancer Network and the Japanese Lung Cancer Society. However, there is no clear evidence comparing the sublobar resections. The less invasive and more generally performed is wedge resection but anatomical segmentectomy may have better survival benefits than wedge resection owing to its superiority in locoregional control. In April 2020, we have initiated a randomized phase III trial in Japan to confirm the superiority of anatomical segmentectomy over wedge resection in high-risk operable patients with clinical stage IA non-small cell lung cancer. We plan to enroll a total of 370 patients from 47 institutions over a period of 5 years. The primary endpoint is overall survival; the secondary endpoints are adverse events, postoperative respiratory function, relapse-free survival, proportion of local recurrence, operative time and blood loss.
(© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.)
