Vitamin D insufficiency as a potential culprit in critical COVID-19 patients.

Tytuł:: Vitamin D insufficiency as a potential culprit in critical COVID-19 patients.
Autorzy:: Munshi R; Division of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Hussein MH; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Toraih EA; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.; Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Elshazli RM; Department of Biochemistry and Molecular Genetics, Faculty of Physical Therapy, Horus University, New Damietta, Egypt.
Jardak C; School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Sultana N; Department of Medicine, Larkin Community Hospital, South Miami, Florida, USA.
Youssef MR; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Omar M; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Attia AS; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Fawzy MS; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia.
Killackey M; Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Kandil E; Division of Endocrine and Oncologic Surgery, Department of Surgery, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Duchesne J; Department of Surgery, Trauma/Acute Care and Critical Care, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Źródło:: Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 733-740. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji:: Journal Article; Meta-Analysis; Systematic Review
Język:: English
Imprint Name(s):: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
MeSH Terms:: COVID-19/*diagnosis
SARS-CoV-2/*pathogenicity
Vitamin D/*blood
Vitamin D Deficiency/*diagnosis
Age Factors ; Biomarkers/blood ; COVID-19/blood ; COVID-19/mortality ; COVID-19/virology ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Odds Ratio ; Prognosis ; ROC Curve ; SARS-CoV-2/metabolism ; Severity of Illness Index ; Survival Analysis ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/mortality ; Vitamin D Deficiency/virology
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Contributed Indexing:: Keywords: COVID-19; SARS-CoV-2; meta-analysis; outcome; vitamin D
Substance Nomenclature:: 0 (Biomarkers)
1406-16-2 (Vitamin D)
Entry Date(s):: Date Created: 20200728 Date Completed: 20210114 Latest Revision: 20210527
Update Code:: 20240104
DOI:: 10.1002/jmv.26360
PMID:: 32716073
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Background: As an immune modulator, vitamin D has been implicated in the coronavirus disease-2019 (COVID-19) outcome. We aim to systematically explore the association of vitamin D serum levels with COVID-19 severity and prognosis.
Methods: The standardized mean difference (SMD) or odds ratio and 95% confidence interval (CI) were applied to estimate pooled results from six studies. The prognostic performance of vitamin D serum levels for predicting adverse outcomes with detection of the best cutoff threshold was determined by receiver operating characteristic curve analysis. Decision tree analysis by combining vitamin D levels and clinical features was applied to predict severity in COVID-19 patients.
Results: Mean vitamin D serum level of 376 patients, was 21.9 nmol/L (95% CI = 15.36-28.45). Significant heterogeneity was found (I 2 = 99.1%, p < .001). Patients with poor prognosis (N = 150) had significantly lower serum levels of vitamin D compared with those with good prognosis (N = 161), representing an adjusted standardized mean difference of -0.58 (95% Cl = -0.83 to -0.34, p < .001).
Conclusion: Serum vitamin D levels could be implicated in the COVID-19 prognosis. Diagnosis of vitamin D deficiency could be a helpful adjunct in assessing patients' potential of developing severe COVID-19. Appropriate preventative and/or therapeutic intervention may improve COVID-19 outcomes.
(© 2020 Wiley Periodicals LLC.)

Comment in: J Med Virol. 2021 Mar;93(3):1225. (PMID: 32990950)
Comment in: J Med Virol. 2021 Jul;93(7):4081-4082. (PMID: 33656189)

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