Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome.

Tytuł:: Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome.
Autorzy:: Outteryck O; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France. .
Lopes R; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Drumez É; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Labreuche J; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Lannoy J; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Hadhoum N; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Boucher J; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Vermersch P; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Zedet M; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Pruvo JP; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Zéphir H; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Leclerc X; From the Department of Neuroradiology, U1171-Degenerative and Vascular Cognitive Disorders, INSERM (O.O., R.L., J.-P.P., X.L.), Department of Biostatistics, EA 2694-Santé Publique: Épidémiologie et Qualité des Soins (É.D., J. Labreuche), and Department of Neurology, U995-Lille Inflammation Research International Center, INSERM (J. Lannoy, N.H., J.B., P.V., M.Z., H.Z.), CHU Lille, Université de Lille, France.
Źródło:: Neurology [Neurology] 2020 Aug 11; Vol. 95 (6), pp. e733-e744. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Minneapolis.
MeSH Terms:: Tomography, Optical Coherence*
Multiple Sclerosis/*diagnostic imaging
Optic Nerve/*diagnostic imaging
Adult ; Asymptomatic Diseases ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis/cerebrospinal fluid ; Oligoclonal Bands/cerebrospinal fluid ; Prospective Studies ; Retina/diagnostic imaging ; Retina/ultrastructure ; Syndrome ; Visual Acuity ; Young Adult
Substance Nomenclature:: 0 (Oligoclonal Bands)
Entry Date(s):: Date Created: 20200730 Date Completed: 20201014 Latest Revision: 20210222
Update Code:: 20240104
DOI:: 10.1212/WNL.0000000000009832
PMID:: 32723802
: Czasopismo naukowe

Objective: To evaluate the ability of intereye retinal thickness difference (IETD) measured by optical coherence tomography (OCT) to detect asymptomatic optic nerve involvement in clinically isolated syndrome (CIS).
Methods: We conducted a cross-sectional study of patients who recently presented a CIS (≤4.5 months). All patients underwent OCT and brain/optic nerve MRI. Optic nerve involvement was defined clinically (episode of optic neuritis [ON] or not) and radiologically (optic nerve hypersignal on 3D double inversion recovery [3D-DIR]). We evaluated the sensitivity and specificity of previously published IETD thresholds and report the observed optimal thresholds for identifying symptomatic optic nerve involvement but also for identifying asymptomatic optic nerve involvement (optic nerve hypersignal without ON history). Primary outcomes were ganglion cell-inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer IETD.
Results: The study group consisted of 130 patients. In the CIS with ON group, 3D-DIR showed a hypersignal in all 41 symptomatic optic nerves and in 11 asymptomatic optic nerves. In the CIS without ON group, 3D-DIR showed a unilateral optic nerve hypersignal in 22 patients and a bilateral optic nerve hypersignal in 7 patients. For the detection of symptomatic and asymptomatic optic nerve lesion, GC-IPL IETD had better performance. We found an optimal GC-IPL IETD threshold ≥2.83 µm (sensitivity 88.2, specificity 83.3%) for the detection of symptomatic lesions and an optimal GC-IPL IETD ≥1.42 µm (sensitivity 89.3%, specificity 72.6%) for the detection of asymptomatic lesions.
Conclusions: Detection of asymptomatic optic nerve lesions in CIS requires lower IETD thresholds than previously reported. GC-IPL IETD represents an alternative biomarker to MRI for the detection of asymptomatic optic nerve lesions.
Classification of Evidence: This study provides Class I evidence that OCT accurately identifies asymptomatic optic nerve involvement in patients with CIS.
(© 2020 American Academy of Neurology.)

Comment in: Neurology. 2020 Aug 11;95(6):239-240. (PMID: 32723803)
Comment in: J Neurol. 2020 Nov;267(11):3436-3438. (PMID: 33030606)
Comment in: Neurology. 2021 Feb 16;96(7):351-352. (PMID: 33589483)
Comment in: Neurology. 2021 Feb 16;96(7):352. (PMID: 33589484)

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