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Tytuł pozycji:

Pharmacokinetics of a Long-Acting Formulation of Oxytetracycline in Freshwater Crocodiles ( Crocodylus siamensis ) after Intramuscular Administration at Three Different Dosages.

Tytuł :
Pharmacokinetics of a Long-Acting Formulation of Oxytetracycline in Freshwater Crocodiles ( Crocodylus siamensis ) after Intramuscular Administration at Three Different Dosages.
Autorzy :
Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Wongwaipairoj T; Wongveerakit Crocodile Farm, Bo Phloi, Kanjanaburi 71160, Thailand.
Giorgi M; Department of Veterinary Science, University of Pisa, 56112 Pisa, Italy.
Chaiyabutr N; Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
Trott DJ; Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Science, University of Adelaide, Roseworthy 5371, Australia.
Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Pokaż więcej
Źródło :
Animals : an open access journal from MDPI [Animals (Basel)] 2020 Jul 27; Vol. 10 (8). Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
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Contributed Indexing :
Keywords: LC-MS/MS; freshwater crocodiles; oxytetracycline; pharmacokinetics
Entry Date(s) :
Date Created: 20200731 Latest Revision: 20200928
Update Code :
20210914
PubMed Central ID :
PMC7459987
DOI :
10.3390/ani10081281
PMID :
32727082
Czasopismo naukowe
To date, the necessary pharmacokinetic information has been limited to establish suitable therapeutic plans for freshwater crocodiles. Therefore, this study was conducted to evaluate the pharmacokinetic profile of the oxytetracycline long-acting formulation (OTC-LA) in the freshwater crocodile, Crocodylus siamensis , following a single intramuscular (i.m.) administration at three different dosages of 5, 10 and 20 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 216 h after i.m. administration at the three different dosages. The plasma concentrations of OTC were measured using a validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) method. The C max (± SD) values of OTC were 2.15 ± 0.51 µg/mL, 7.68 ± 1.08 µg/mL and 17.08 ± 2.09 µg/mL at doses of 5, 10 and 20 mg/kg b.w., respectively. The elimination half-life values were 33.59 ± 2.51 h, 38.42 ± 5.47 h and 38.04 ± 1.98 h at dosages of 5, 10 and 20 mg/kg b.w., respectively. Based on the pharmacokinetic data, the pharmacokinetic/pharmacodynamic (PK/PD) index, the susceptibility break-point and plasma protein binding, a dosage once every two weeks of 10 mg/kg b.w. OTC intramuscularly might be suitable for initiating the treatment of susceptible bacterial infections in freshwater crocodiles. However, further PK/PD studies are warranted to confirm whether the dose rates used in this study can produce longer-term antimicrobial success for diseases caused by susceptible bacteria in freshwater crocodiles.

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