The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity.

Tytuł:: The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity.
Autorzy:: Araújo-Martins J; Otolaryngology, Hospital de Torres Vedras, Centro Hospitalar do Oeste - Torres Vedras, Rua Dr. Aurélio Ricardo Belo, 2560-364, Torres Vedras, Portugal. .; Environmental Health Research Group, CHRC/CEDOC, NOVA Medical School, Lisboa, Portugal. .
Brás-Geraldes C; Centro de Estatística e Aplicações, Universidade de Lisboa, Lisboa, Portugal.; ADM - Instituto Superior de Engenharia de Lisboa, Lisboa, Portugal.
Neuparth N; Environmental Health Research Group, CHRC/CEDOC, NOVA Medical School, Lisboa, Portugal.
Źródło:: Scientific reports [Sci Rep] 2020 Jul 29; Vol. 10 (1), pp. 12674. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Adrenal Cortex Hormones/*administration & dosage
Clarithromycin/*administration & dosage
Leukotriene Antagonists/*administration & dosage
Nasal Obstruction/*diagnosis
Nasal Polyps/*pathology
Rhinomanometry/*methods
Sinusitis/*pathology
Administration, Intranasal ; Administration, Topical ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Case-Control Studies ; Clarithromycin/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; Leukotriene Antagonists/therapeutic use ; Male ; Middle Aged ; Nasal Obstruction/drug therapy ; Nasal Polyps/drug therapy ; Prospective Studies ; Reproducibility of Results ; Rhinomanometry/instrumentation ; Severity of Illness Index ; Sinusitis/drug therapy ; Treatment Outcome
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Substance Nomenclature:: 0 (Adrenal Cortex Hormones)
0 (Leukotriene Antagonists)
H1250JIK0A (Clarithromycin)
Entry Date(s):: Date Created: 20200731 Date Completed: 20201216 Latest Revision: 20210729
Update Code:: 20240104
PubMed Central ID:: PMC7391672
DOI:: 10.1038/s41598-020-69693-6
PMID:: 32728055
: Czasopismo naukowe

Pełny tekst

Although the pathophysiology of nasal polyposis is incompletely understood, rhinologists have seldom studied it with rhinomanometry or peak nasal inspiratory flow (PNIF) due to technical limitations and the perception that polyp size might impair reproducibility and the usefulness of recordings. The objective of this study is to assess how measures of rhinomanometry and PNIF relate to disease activity. Nineteen patients with polyps, 15 patients with chronic sinusitis without polyps and 11 negative controls were evaluated with active anterior rhinomanometry and PNIF. Sinusitis and polyp patients were re-evaluated after medical treatment. Polyp patients had the highest median Lund-Mackay score (14) and a median Johansen score of 1. PNIF and its variation after treatment were also lowest in this group (median 90 L/min before and after treatment; median variation of 0 L/min). Nasal resistance was similar between groups, and only correlated with Johansen score (Spearman = 0.517, p = 0.048) after treatment. Our study suggests that evaluating polyp patients using rhinomanometry and PNIF may provide useful and reproducible data. Several findings considered together suggest that polyp size is not the main determinant of nasal functional changes in these patients, warranting further studies to verify whether PNIF changes reflect sinus inflammation or merely airway obstruction.

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