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Tytuł:
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Synthesis of Se-polysaccharide mediated by selenium oxychloride: Structure features and antiproliferative activity.
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Autorzy:
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Zhu S; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Hu J; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Liu S; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Guo S; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Jia Y; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Li M; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Kong W; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Liang J; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Zhang J; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China.
Wang J; College of Life Science, Northwest Normal University, Lanzhou 730070, People's Republic of China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, People's Republic of China. Electronic address: .
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Źródło:
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Carbohydrate polymers [Carbohydr Polym] 2020 Oct 15; Vol. 246, pp. 116545. Date of Electronic Publication: 2020 Jun 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
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MeSH Terms:
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Cell Proliferation/*drug effects
Plant Extracts/*chemistry
Polysaccharides/*chemistry
Selenium/*chemistry
Selenium Compounds/*chemical synthesis
Selenium Compounds/*pharmacology
A549 Cells ; Artemisia/chemistry ; Hep G2 Cells ; Humans ; Kinetics ; Magnetic Resonance Spectroscopy ; Microscopy, Atomic Force ; Microwaves ; Nitric Acid/chemistry ; Photoelectron Spectroscopy ; Selenious Acid/chemistry ; Selenium Compounds/radiation effects ; Spectroscopy, Fourier Transform Infrared
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Contributed Indexing:
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Keywords: Antiproliferative effect; Artemisia sphaerocephala; Microwave-assisted synthesis; Selenized polysaccharide
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Substance Nomenclature:
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0 (Plant Extracts)
0 (Polysaccharides)
0 (Selenium Compounds)
411VRN1TV4 (Nitric Acid)
F6A27P4Q4R (Selenious Acid)
H6241UJ22B (Selenium)
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Entry Date(s):
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Date Created: 20200805 Date Completed: 20210402 Latest Revision: 20210402
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Update Code:
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20240105
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DOI:
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10.1016/j.carbpol.2020.116545
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PMID:
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32747234
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Selenium oxychloride (SOC) was employed as a highly reactive selenide reagent to synthesize selenized Artemisia sphaerocephala polysaccharides (SeASP). Se content of SeASP was significantly increased (∼22,400 μg/g) as compared to HNO 3 /H 2 SeO 3 selenylation method (1703 μg/g). Furthermore, selenized ASP was prepared by using microwave-assisted synthesis which obviously enhanced selenylation kinetics. FT-IR, Raman, XPS and NMR results exhibited seleno-group was substituted at C6 position in the form of selenite (Se 4+ ). SEC-MALLS suggested SOC system could effectively avoid the degradation of polysaccharide chain. Meanwhile, MALLS calculation, MB spectrophotometric method and AFM observation showed SeASP appeared spherical and rod-shaped conformation after selenylation. Seleno-groups were more likely to affect the conformational transformation of polysaccharide chains. Moreover, SeASP could significantly enhance antiproliferative activity against three tumor cells, of which the IC 50 value of HepG2 was calculated as 24.35 μg/mL. It was found that higher Se content could effectively improve the antitumor activities of Se-polysaccharides in vitro.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)