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Tytuł pozycji:

Age-Associated Role of Lingual and Pharyngeal Glands in Local Immunity in Oral Cavity.

Tytuł :
Age-Associated Role of Lingual and Pharyngeal Glands in Local Immunity in Oral Cavity.
Autorzy :
Olsufieva AV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. .
Bodrova IV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Vasyanina KA; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Vovkogon AD; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Olsufiev SS; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Chizh RS; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Jul; Vol. 169 (3), pp. 373-377. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
Contributed Indexing :
Keywords: lingual and pharyngeal glands; local immunity; lymphoid tissue; oral cavity; secretory IgA
Entry Date(s) :
Date Created: 20200805 Latest Revision: 20200811
Update Code :
20201218
DOI :
10.1007/s10517-020-04890-x
PMID :
32748137
Czasopismo naukowe
The macroscopic and histological methods were employed to examine the autopsy specimens of salivary lingual glands obtained from 299 patients of both sexes and various age ranging from newborn to longevity. The age-associated alterations of minor lingual and pharyngeal glands were revealed, and the topographical relations between the glands and lymphoid cells were described. The characteristic sparsity of the glands in infancy is caused by nutritional uniformity at this period, when diminished production of secretory IgA results in frequent inflammatory processes in oral and pharyngeal cavities. With age, the glandular orifices widen, and their number increases thereby augmenting local immunity in the oral cavity and in oral aspect of the pharynx. Starting from elderly and senile age, the involutive alterations were observed, which were accompanied by diminished production of secretory immunoglobulin A and related degradation of local and humoral immunity.

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