-
Tytuł:
-
Cobalt accumulation and iron-regulatory protein profile expression in immature mouse brain after perinatal exposure to cobalt chloride.
-
Autorzy:
-
Petrova E; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, 1113, Sofia, Bulgaria. Electronic address: .
Pavlova E; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, 1113, Sofia, Bulgaria. Electronic address: e_.
Tinkov AA; P G Demidov Yaroslavl State University, Sovetskaya Str., 14, Yaroslavl, 150000, Russia; I M Sechenov First Moscow State Medical University, Moscow, 119146, Russia. Electronic address: .
Ajsuvakova OP; P G Demidov Yaroslavl State University, Sovetskaya Str., 14, Yaroslavl, 150000, Russia; Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg, 460000, Russia. Electronic address: .
Skalny AV; I M Sechenov First Moscow State Medical University, Moscow, 119146, Russia; Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg, 460000, Russia. Electronic address: .
Rashev P; Institute of Biology and Immunology of Reproduction 'Acad. Kiril Bratanov', Bulgarian Academy of Sciences, Tsarigradsko shose Blvd 73, 1113, Sofia, Bulgaria. Electronic address: pavel_.
Vladov I; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, 1113, Sofia, Bulgaria. Electronic address: .
Gluhcheva Y; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 25, 1113, Sofia, Bulgaria. Electronic address: .
-
Źródło:
-
Chemico-biological interactions [Chem Biol Interact] 2020 Sep 25; Vol. 329, pp. 109217. Date of Electronic Publication: 2020 Aug 01.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Limerick : Elsevier
Original Publication: Amsterdam, Elsevier.
-
MeSH Terms:
-
Brain/*metabolism
Cobalt/*pharmacology
Gene Expression Regulation, Developmental/*drug effects
Iron-Regulatory Proteins/*metabolism
Animals ; Body Weight/drug effects ; Brain/drug effects ; Brain/growth & development ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Cobalt/metabolism ; Female ; Hepcidins/genetics ; Hepcidins/metabolism ; Iron/metabolism ; Iron-Regulatory Proteins/genetics ; Mice ; Mice, Inbred ICR ; Pregnancy ; Prenatal Exposure Delayed Effects ; Receptors, Transferrin/genetics ; Receptors, Transferrin/metabolism
-
Contributed Indexing:
-
Keywords: Cobalt; Ferroportin; Hepcidin; Immature brain; Iron; Transferrin receptor 1
-
Substance Nomenclature:
-
0 (Cation Transport Proteins)
0 (Hepcidins)
0 (Iron-Regulatory Proteins)
0 (Receptors, Transferrin)
0 (Tfrc protein, mouse)
0 (metal transporting protein 1)
3G0H8C9362 (Cobalt)
E1UOL152H7 (Iron)
EVS87XF13W (cobaltous chloride)
-
Entry Date(s):
-
Date Created: 20200805 Date Completed: 20201013 Latest Revision: 20201013
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.cbi.2020.109217
-
PMID:
-
32750324
-
Developing brain is very sensitive to the influence of environmental factors during gestation and the neonatal period. The aim of the study is to assess cobalt and iron accumulation in the brain as well as changes in the expression of iron-regulatory proteins transferrin receptor 1, hepcidin, and ferroportin in suckling mice. Perinatal exposure to cobalt chloride increased significantly cobalt content in brain tissue homogenates of 18-day-old (d18) and 25-day-old (d25) mice inducing alterations in brain iron homeostasis. Higher degree of transferrin receptor 1 expression was demonstrated in cobalt chloride-exposed mice with no substantial changes between d18 and d25 mice. A weak ferroportin expression was found in 18-day-old control and cobalt-treated mouse brain. Cobalt exposure of d25 mice resulted in increased ferroportin expression in brain compared to the untreated age-matched control group. Hepcidin level in cobalt-exposed groups was decreased in d18 mice and slightly increased in d25 mice. The obtained data contribute for the better understanding of metal toxicity impact on iron homeostasis in the developing brain with further possible implications in neurodegeneration.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
