A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.

Tytuł:: A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.
Autorzy:: Strait AM; 22916Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Linos K; 22916Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Tafe LJ; 22916Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Muller KE; 22916Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Źródło:: International journal of surgical pathology [Int J Surg Pathol] 2021 May; Vol. 29 (3), pp. 308-313. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Publication: Thousand Oaks, CA : Sage Publications
Original Publication: Naperville, IL : Churchill Livingstone, c1993-
MeSH Terms:: Breast/*pathology
Breast Neoplasms, Male/*diagnosis
Neoplasms, Complex and Mixed/*diagnosis
Neoplasms, Muscle Tissue/*diagnosis
Aged ; Biomarkers, Tumor/genetics ; Breast/surgery ; Breast Neoplasms, Male/genetics ; Breast Neoplasms, Male/pathology ; Breast Neoplasms, Male/surgery ; Chromosomes, Human, Pair 13/genetics ; DNA Copy Number Variations ; Diagnosis, Differential ; Humans ; Male ; Neoplasms, Complex and Mixed/pathology ; Neoplasms, Complex and Mixed/surgery ; Neoplasms, Muscle Tissue/genetics ; Neoplasms, Muscle Tissue/pathology ; Neoplasms, Muscle Tissue/surgery
Contributed Indexing:: Keywords: Rb protein; cellular angiofibroma; myofibroblastoma; retinoblastoma protein; sarcoma; spindle cell lipoma
Substance Nomenclature:: 0 (Biomarkers, Tumor)
Entry Date(s):: Date Created: 20200806 Date Completed: 20210823 Latest Revision: 20210823
Update Code:: 20240105
DOI:: 10.1177/1066896920947465
PMID:: 32752900
: Czasopismo naukowe

Pełny tekst

Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breast of a 70-year old man that microscopically showed an abrupt transition from classic MFB morphology to an area with cytologic atypia and mitotic activity, akin to sarcomatous transformation described in cellular angiofibromas. A thorough workup of the molecular underpinnings of both components using chromosomal microarray and next-generation sequencing platforms supported a clonal relationship. Nearly identical copy number changes, including a single copy loss of 13q14, were found in both components; in addition, the sarcomatous component harbored biallelic TP53 alterations. It is important for pathologists to recognize that sarcomatous features can occur in mammary-type MFB to arrive at the correct diagnosis.

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