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Tytuł:
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Bismuth chelate as a contrast agent for X-ray computed tomography.
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Autorzy:
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Fu JJ; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China. .; School of Materials Science and Energy Engineering, Foshan University, Foshan, 528000, China. .
Guo JJ; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Medical Imaging, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Qin AP; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Yu XY; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Zhang Q; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Lei XP; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Huang YG; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Chen MY; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Li JX; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Zhang Y; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Liu JP; The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Dang YY; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Wu D; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Zhao XY; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Lin ZX; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China.
Lin YL; School of Materials Science and Energy Engineering, Foshan University, Foshan, 528000, China.
Li SP; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510700, Guangdong, China. .
Zhang LY; Department of Medical Imaging, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. .
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Źródło:
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Journal of nanobiotechnology [J Nanobiotechnology] 2020 Aug 06; Vol. 18 (1), pp. 110. Date of Electronic Publication: 2020 Aug 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, 2003-
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MeSH Terms:
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Bismuth*/chemistry
Bismuth*/pharmacokinetics
Bismuth*/toxicity
Contrast Media*/chemistry
Contrast Media*/pharmacokinetics
Contrast Media*/toxicity
Tomography, X-Ray Computed/*methods
Animals ; Iohexol/chemistry ; Iohexol/pharmacokinetics ; Kidney/diagnostic imaging ; Kidney/metabolism ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Mice ; Pentetic Acid/chemistry ; Pentetic Acid/pharmacokinetics ; Tissue Distribution ; Whole Body Imaging
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References:
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Grant Information:
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81803463 National Natural Science Foundation of China; 81903607 National Natural Science Foundation of China; 81870142 National Natural Science Foundation of China; 51403043 National Natural Science Foundation of China; 51803028 National Natural Science Foundation of China; 2018A030310183 Natural Science Foundation of Guangdong Province; 2015A030310428 Natural Science Foundation of Guangdong Province; 907181975046 Science and Technology Program of Guangzhou; 20201208 Traditional Chinese Medicine Program of Guangdong Province; gg07077 the scientific research start-up fund for high-level talents of Foshan University, China
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Contributed Indexing:
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Keywords: Bismuth agent; DTPA; Iohexol; X-ray computed tomography
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Substance Nomenclature:
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0 (Contrast Media)
4419T9MX03 (Iohexol)
7A314HQM0I (Pentetic Acid)
U015TT5I8H (Bismuth)
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Entry Date(s):
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Date Created: 20200809 Date Completed: 20210430 Latest Revision: 20210430
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Update Code:
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20240105
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PubMed Central ID:
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PMC7412782
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DOI:
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10.1186/s12951-020-00669-4
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PMID:
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32762751
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Backgrounds: Due to the unexpected side effects of the iodinated contrast agents, novel contrast agents for X-ray computed tomography (CT) imaging are urgently needed. Nanoparticles made by heavy metal elements are often employed, such as gold and bismuth. These nanoparticles have the advantages of long in vivo circulation time and tumor targeted ability. However, due to the long residence time in vivo, these nanoparticles may bring unexpected toxicity and, the preparation methods of these nanoparticles are complicated and time-consuming.
Methods: In this investigation, a small molecular bismuth chelate using diethylenetriaminepentaacetic acid (DPTA) as the chelating agent was proposed to be an ideal CT contrast agent.
Results: The preparation method is easy and cost-effective. Moreover, the bismuth agent show better CT imaging for kidney than iohexol in the aspect of improved CT values. Up to 500 µM, the bismuth agent show negligible toxicity to L02 cells and negligible hemolysis. And, the bismuth agent did not induce detectable morphology changes to the main organs of the mice after intravenously repeated administration at a high dose of 250 mg/kg. The pharmacokinetics of the bismuth agent follows the first-order elimination kinetics and, it has a short half-life time of 0.602 h. The rapid clearance from the body promised its excellent biocompatibility.
Conclusions: This bismuth agent may serve as a potential candidate for developing novel contrast agent for CT imaging in clinical applications.
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