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Tytuł pozycji:

Effect of psychotropic drugs on cortical excitability of patients with major depressive disorders: A transcranial magnetic stimulation study.

Tytuł :
Effect of psychotropic drugs on cortical excitability of patients with major depressive disorders: A transcranial magnetic stimulation study.
Autorzy :
Khedr EM; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address: .
Elserogy Y; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Fawzy M; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abdelrahman AA; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Galal AM; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Noaman MM; Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
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Źródło :
Psychiatry research [Psychiatry Res] 2020 Sep; Vol. 291, pp. 113287. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
MeSH Terms :
Antipsychotic Agents/*therapeutic use
Cortical Excitability/*drug effects
Depressive Disorder, Major/*physiopathology
Motor Cortex/*drug effects
Motor Cortex/*physiopathology
Transcranial Magnetic Stimulation/*drug effects
Adult ; Antipsychotic Agents/pharmacology ; Cortical Excitability/physiology ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/psychology ; Evoked Potentials, Motor/drug effects ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Psychiatric Status Rating Scales ; Transcranial Magnetic Stimulation/psychology ; Young Adult
Contributed Indexing :
Keywords: Beck depression inventory*; Cortical excitability*; Cortical silent period*; DSM-V*; GABA*; Glutamate*; Major depressive disorder*; Motor threshold*; Olanzapine*; Psychotropic drugs*; Quetiapine*; Sertraline*; Transcranial magnetic stimulation*
Substance Nomenclature :
0 (Antipsychotic Agents)
Entry Date(s) :
Date Created: 20200809 Date Completed: 20201231 Latest Revision: 20201231
Update Code :
20210623
DOI :
10.1016/j.psychres.2020.113287
PMID :
32763548
Czasopismo naukowe
Transcranial magnetic stimulation (TMS) can be used to evaluate the effects of pharmacological interventions. The aim of this study was to assess the impact of the selective serotonin reuptake inhibitor, sertraline, and the atypical antipsychotic drugs quetiapine and olanzapine, on cortical excitability in unmedicated patients with major depressive disorder (MDD). The study included 45 medication-free MDD patients diagnosed according to DSM V. They were divided randomly into three groups who received a single oral dose of one of the three drugs sertraline (50 mg), quetiapine (100 mg) and olanzapine (10 mg). Psychological evaluation was conducted using the Mini-Mental State Examination (MMSE) and Beck Depression Inventory Scale (BDI). Resting and active motor thresholds (rMT and aMT) together with contralateral and ipsilateral cortical silent periods (cSP, and iSP) were measured for each participant before and at the time of maximum concentration of drug intake. There was significant increase in excitability of motor cortex after sertraline without changes in GABA B neurotransmission. Quetiapine and olanzapine potentiated inhibitory GABA B neurotransmission (prolongation of cSP); olanzapine additionally prolonged the iSP. Thus TMS can differentiate between the impact of different psychotropic drugs on excitatory and inhibitory transmission in motor cortex.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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