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Tytuł pozycji:

Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic.

Tytuł:
Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic.
Autorzy:
Kulyar MF; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
Li R; Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
Mehmood K; Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur-63100, Pakistan.
Waqas M; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Faculty of Veterinary & Animal Sciences, University of the Poonch, Rawalakot, District Poonch 12350, Azad Jammu & Kashmir, Pakistan.
Li K; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: .
Li J; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: .
Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 May; Vol. 85, pp. 153277. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: Stuttgart : Urban & Fischer Verlag
Original Publication: Stuttgart ; New York : G. Fischer, c1994-
MeSH Terms:
COVID-19 Drug Treatment*
Immune System/*drug effects
Nigella sativa/*chemistry
Plant Extracts/*pharmacology
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Benzoquinones/pharmacology ; Drug Evaluation, Preclinical ; Humans ; Molecular Docking Simulation ; Oleanolic Acid/pharmacology ; Pandemics ; SARS-CoV-2/drug effects
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Contributed Indexing:
Keywords: Black seed; Coronavirus; Covid-19; Immunomodulation; Nagella sativa; Nigellidine; Thymoquinone; α-hederin
Substance Nomenclature:
0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Benzoquinones)
0 (Plant Extracts)
6SMK8R7TGJ (Oleanolic Acid)
O60IE26NUF (thymoquinone)
Entry Date(s):
Date Created: 20200811 Date Completed: 20210428 Latest Revision: 20221219
Update Code:
20240105
PubMed Central ID:
PMC7347483
DOI:
10.1016/j.phymed.2020.153277
PMID:
32773257
Czasopismo naukowe
The world is witnessing a difficult time. The race of developing a new coronavirus (COVID-19) vaccine is becoming more urgent. Many preliminary studies on the pathophysiology of COVID-19 patients have provided some clues to treat this pandemic. However, no suitable treatment has found yet. Various symptoms of patients infected with COVID-19 indicated the importance of immune regulation in the human body. Severe cases admitted to the intensive care unit showed high level of pro-inflammatory cytokines which enhanced the disease severity. Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients is another critical factor of disease severity and mortality. So, Immune modulation is the only way of regulating immune system. Nigella sativa has been used for medicinal purposes for centuries. The components of this plant are known for its intense immune-regulatory, anti-inflammatory, and antioxidant benefits in obstructive respiratory disorders. A molecular docking study also gave evidences that N. sativa decelerates COVID-19 and might give the same or better results than the FDA approved drugs. The aim of this review was to investigate the possible immune-regulatory effects of N. sativa on COVID-19 pandemic. Our review found N. sativa's Thymoquinone, Nigellidine, and α-hederin can be a potential influencer in reinforcing the immune response on molecular grounds.
(Copyright © 2020 Elsevier GmbH. All rights reserved.)

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