Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Altered cortical functional network in drug-naive adult male patients with attention-deficit hyperactivity disorder: A resting-state electroencephalographic study.

Tytuł :
Altered cortical functional network in drug-naive adult male patients with attention-deficit hyperactivity disorder: A resting-state electroencephalographic study.
Autorzy :
Kim S; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Kim JS; Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
Kwon YJ; Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
Lee HY; Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
Yoo JH; Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee YJ; Department of Psychiatry, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
Shim SH; Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2021 Mar 02; Vol. 106, pp. 110056. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Oxford ; New York : Pergamon Press, c1982-
Contributed Indexing :
Keywords: Adult ADHD; Cortical functional network; Drug-naive; Graph theory; Resting-state EEG
Entry Date(s) :
Date Created: 20200811 Latest Revision: 20201221
Update Code :
20210210
DOI :
10.1016/j.pnpbp.2020.110056
PMID :
32777325
Czasopismo naukowe
Relatively little is known about the neurophysiology of adult Attention-deficit/hyperactivity disorder (ADHD). Brain network analysis can yield important insights into the neuropathology in adult ADHD. The objective of this study was to investigate source-level cortical functional network using resting-state electroencephalography (EEG) in drug-naive adult patients with ADHD. Resting-state EEG was performed for 30 adult male patients with ADHD and 27 male healthy controls. Source-level weighted functional networks based on graph theory were evaluated, including strength, clustering coefficient (CC) and path length (PL) in six frequency bands. At the global level, strength (η 2  = 0.167) and CC (η 2  = 0.156) were lower while PL (η 2  = 0.159) was higher for the high beta band in the ADHD patient group compared to healthy controls. At the nodal level, CCs of the high beta band were lower in the left middle temporal gyrus (η 2  = 0.244), right inferior occipital cortex (η 2  = 0.214), right posterior transverse collateral sulcus (η 2  = 0.237), and right anterior occipital sulcus (η 2  = 0.251) for the adult ADHD group. Furthermore, the nodal-level high beta band CCs of the left middle temporal gyrus and right anterior occipital sulcus were significantly negatively correlated with ADHD symptoms. The altered cortical functional network showed inefficient connectivity in the left middle temporal gyrus, belonging to the default mode network, the right inferior occipital cortex, belonging to the extrastriate visual resting state network, the right posterior transverse collateral sulcus, belonging to the visual network, and the anterior occipital sulcus, reflecting visual attention, which might affect the pathophysiology of ADHD. Taken together, these attenuated network inefficiencies in adult patients with ADHD may lead to suboptimal information processing and affect symptoms of ADHD, such as inattention and hyperactivity. Our findings should be further replicated using longitudinal study designs.
(Copyright © 2020. Published by Elsevier Inc.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies