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Title of the item:

Establishment of reference intervals for pediatric complete capillary blood counts: A multicenter study in Beijing.

Title :
Establishment of reference intervals for pediatric complete capillary blood counts: A multicenter study in Beijing.
Authors :
Sun Q; Department of Clinical Laboratory, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China.
Yue Y; Department of Clinical Laboratory, Beijing Center for Clinical Laboratories, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Tian Y; Department of Clinical Laboratory, Beijing Chaoyang District Maternal and Child Health Care Hospital, Beijing, China.
Wang Q; Department of Clinical Laboratory, Beijing Center for Clinical Laboratories, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
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Source :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Oct; Vol. 42 (5), pp. 533-543. Date of Electronic Publication: 2020 Aug 13.
Publication Type :
Journal Article
Language :
English
Imprint Name(s) :
Original Publication: Oxford : Blackwell Scientific Publications, c2007-
MeSH Terms :
Reference Values*
Blood Cell Count/*methods
Age Factors ; Beijing ; Blood Cell Count/instrumentation ; Blood Cell Count/standards ; Child ; Child, Preschool ; Female ; Healthy Volunteers ; Hematocrit ; Humans ; Infant ; Male
References :
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Grant Information :
ZYLX201805 Clinical Medicine Development of Beijing Hospital Administration; National Key Clinical Specialty Construction Program
Contributed Indexing :
Keywords: blood cell analysis; capillary blood; multicenter; pediatric; reference interval
Entry Date(s) :
Date Created: 20200814 Date Completed: 20210208 Latest Revision: 20210208
Update Code :
20210623
DOI :
10.1111/ijlh.13150
PMID :
32790150
Academic Journal
Introduction: Clinical reference intervals represent the normal range of clinical parameters for distinguishing healthy and sick individuals, and they show some variation among different populations. Many reference intervals are still lacking for the pediatric population in China. Thus, the aim of this study was to establish and validate pediatric reference intervals for capillary blood cell counts.
Methods: A total of 9942 children were enrolled from 10 medical institutions in Beijing, China, for capillary complete blood count (CCBC) values according to the EP28-A3c guideline issued by the Clinical and Laboratory Standards Institute.
Results: Pediatric reference intervals for 17 CCBC parameters were established for children aged 6 months to 7 years. The red blood cell count and red blood cell distribution width were generally higher in males than in females, and the mean corpuscular hemoglobin and mean corpuscular volume were higher in females than in males. The red blood cell, hemoglobin, hematocrit, and neutrophil percentages increased while the percentage of lymphocytes decreased with age. The overall trends for each reference interval were relatively similar in different ethnic groups and regions in the world, but with variation in the upper and lower limits, which confirms the existence of racial and geographical differences. Further validation with 508 healthy subjects showed that the verified proportions were within 90.9%-100% of the reference intervals.
Conclusions: This study offers local reference intervals for CCBC values for the pediatric population in Beijing, China, and thus provides basic criteria for the diagnosis, treatment, and health assessment of childhood diseases in China.
(© 2020 John Wiley & Sons Ltd.)

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