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Tytuł pozycji:

Lymph nodes-The neglected battlefield in tuberculosis.

Tytuł :
Lymph nodes-The neglected battlefield in tuberculosis.
Autorzy :
Ganchua SKC; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
White AG; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Klein EC; Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Flynn JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.; Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 13; Vol. 16 (8), pp. e1008632. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język :
English
Imprint Name(s) :
Original Publication: San Francisco, CA : Public Library of Science, c2005-
MeSH Terms :
Lung/*immunology
Lymph Nodes/*immunology
Mycobacterium tuberculosis/*immunology
Tuberculosis/*immunology
Tuberculosis/*pathology
Tuberculosis Vaccines/*immunology
Animals ; Humans ; Lung/microbiology ; Lymph Nodes/microbiology ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/microbiology ; Tuberculosis/prevention & control
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Substance Nomenclature :
0 (Tuberculosis Vaccines)
Entry Date(s) :
Date Created: 20200814 Date Completed: 20200922 Latest Revision: 20200922
Update Code :
20201023
PubMed Central ID :
PMC7425845
DOI :
10.1371/journal.ppat.1008632
PMID :
32790739
Czasopismo naukowe
Lymph nodes, particularly thoracic lymph nodes, are among the most common sites of extrapulmonary tuberculosis (TB). However, Mycobacterium tuberculosis (Mtb) infection in these organs is understudied. Aside from being sites of initiation of the adaptive immune system, lymph nodes also serve as niches of Mtb growth and persistence. Mtb infection results in granuloma formation that disrupts and-if it becomes large enough-replaces the normal architecture of the lymph node that is vital to its function. In preclinical models, successful TB vaccines appear to prevent spread of Mtb from the lungs to the lymph nodes. Reactivation of latent TB can start in the lymph nodes resulting in dissemination of the bacteria to the lungs and other organs. Involvement of the lymph nodes may improve Bacille Calmette-Guerin (BCG) vaccine efficacy. Lastly, drug penetration to the lymph nodes is poor compared to blood, lung tissue, and lung granulomas. Future studies on evaluating the efficacy of vaccines and anti-TB drug treatments should include consideration of the effects on thoracic lymph nodes and not just the lungs.
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