Clinical implications of agoraphobia in patients with panic disorder.

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Tytuł:: Clinical implications of agoraphobia in patients with panic disorder.
Autorzy:: Shin J; Department of Psychiatry, Konkuk University Medical Center.
Park DH; Department of Psychiatry, Konkuk University Medical Center.; Department of Psychiatry, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Ryu SH; Department of Psychiatry, Konkuk University Medical Center.; Department of Psychiatry, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Ha JH; Department of Psychiatry, Konkuk University Medical Center.; Department of Psychiatry, School of Medicine, Konkuk University, Seoul, Republic of Korea.
Kim SM; Department of Psychiatry, Konkuk University Medical Center.
Jeon HJ; Department of Psychiatry, Konkuk University Medical Center.
Źródło:: Medicine [Medicine (Baltimore)] 2020 Jul 24; Vol. 99 (30), pp. e21414.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:: Agoraphobia/*complications
Panic Disorder/*complications
Adult ; Agoraphobia/psychology ; Benzodiazepines/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Panic Disorder/drug therapy ; Panic Disorder/psychology ; Retrospective Studies ; Young Adult
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Substance Nomenclature:: 12794-10-4 (Benzodiazepines)
Entry Date(s):: Date Created: 20200815 Date Completed: 20200821 Latest Revision: 20221005
Update Code:: 20240105
PubMed Central ID:: PMC7387026
DOI:: 10.1097/MD.0000000000021414
PMID:: 32791758
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Agoraphobia is frequently accompanied by panic disorder and causes considerable suffering. The aim of this study was to compare clinical features and treatment courses between patients with and without agoraphobia in panic disorder.In this retrospective study, 87 patients with panic disorder were divided into two groups depending on the presence of agoraphobia: patients with agoraphobia (PDA, n = 41) and patients without agoraphobia (PD, n = 46). Agoraphobia subscale score of the Albany Panic and Phobia Questionnaire was used to identify correlations between agoraphobia and panic and affective symptoms.The PDA group showed more severe panic and affective symptoms than the PD group. Patients with PDA were more likely to be younger at the age of onset, take benzodiazepines for longer durations, and be treated with antipsychotics augmentation. Agoraphobia subscale was associated with panic symptoms, depression, anxiety, and the duration of benzodiazepines use.The findings suggest that patients with PDA experienced more severe panic symptoms, more profound psychiatric comorbidity, and worse illness progression than those with PD.

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