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Tytuł:
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Nephrotoxic effects caused by co-exposure to noise and toluene in New Zealand white rabbits: A biochemical and histopathological study.
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Autorzy:
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Abouee-Mehrizi A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Occupational Health Engineering, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Rasoulzadeh Y; Department of Occupational Health Engineering, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
Mesgari-Abbasi M; Drug Applied Research Center (DARC), Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdipour A; Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Ebrahimi-Kalan A; Neurosciences Research Center (NRC), Department of Cognitive and Neurosciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
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Źródło:
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Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118254. Date of Electronic Publication: 2020 Aug 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
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MeSH Terms:
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Kidney/*drug effects
Noise/*adverse effects
Toluene/*toxicity
Animals ; Antioxidants/pharmacology ; Catalase/metabolism ; Cholesterol/metabolism ; Creatinine/metabolism ; Female ; Glucose/metabolism ; Glutathione Peroxidase/metabolism ; Kidney/metabolism ; Kidney Diseases/pathology ; Male ; Malondialdehyde/metabolism ; Oxidative Stress/drug effects ; Rabbits ; Superoxide Dismutase/metabolism ; Toluene/metabolism ; Toluene/pharmacology ; Urea/metabolism ; Uric Acid/metabolism
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Contributed Indexing:
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Keywords: Nephrology; Noise; Occupational health; Pathology; Toluene; Toxicology
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Substance Nomenclature:
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0 (Antioxidants)
268B43MJ25 (Uric Acid)
3FPU23BG52 (Toluene)
4Y8F71G49Q (Malondialdehyde)
8W8T17847W (Urea)
97C5T2UQ7J (Cholesterol)
AYI8EX34EU (Creatinine)
EC 1.11.1.6 (Catalase)
EC 1.11.1.9 (Glutathione Peroxidase)
EC 1.15.1.1 (Superoxide Dismutase)
IY9XDZ35W2 (Glucose)
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Entry Date(s):
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Date Created: 20200818 Date Completed: 20201104 Latest Revision: 20201104
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Update Code:
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20240105
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DOI:
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10.1016/j.lfs.2020.118254
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PMID:
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32800833
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The biological and renal effects made by simultaneous and non-simultaneous exposure to toluene and noise were investigated. Twenty-four New Zealand white rabbits were exposed to 100 dB of white noise and 1000 ppm of toluene vapor for two weeks. The examined biochemical factors were urea, uric acid, creatinine, glucose, triglyceride, cholesterol, and albumin serum levels, measured on different days after the end of the exposure. Moreover, glutathione peroxidase activity (GPX), malondialdehyde dismutase activity (MDA), and superoxide dismutase (SOD) parameters were measured in the kidney tissue. The hematoxylin and eosin staining method was used for histopathological experiments. Overall, the noise increased albumin, uric acid, creatinine, and glucose levels, but it decreased urea, cholesterol, and triglyceride levels. Toluene decreased albumin, uric acid, and urea levels, while it increased creatinine, triglyceride, cholesterol, and glucose levels. Simultaneous exposure to noise and toluene decreased albumin, uric acid, cholesterol, and urea levels, whereas it increased creatinine, glucose, and triglyceride levels. GPX, MDA, and SOD levels increased by simultaneous and non-simultaneous exposure to noise and toluene. Furthermore, massive tubular degeneration, tubular cell vacuolization, glomerular disorganization, congestion, glomerular cell shrinkage, and unclear brush border were detected in the kidney tissue.
Competing Interests: Declaration of competing interest This research was conducted independently with no organizational affiliation. The authors are responsible for publishing the content of this paper.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
