Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial.

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Abstrakt

Tytuł:: Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial.
Autorzy:: Aggour RL; Department of Oral Medicine &Periodontology, Faculty of Dentistry, October 6 University, Cairo, Egypt. .
Mahmoud SH; Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Abdelwhab A; Department of Oral Medicine &Periodontology, Faculty of Dentistry, October 6 University, Cairo, Egypt.
Źródło:: Clinical oral investigations [Clin Oral Investig] 2021 Apr; Vol. 25 (4), pp. 2151-2158. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji:: Journal Article; Randomized Controlled Trial
Język:: English
Imprint Name(s):: Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
MeSH Terms:: Probiotics*/therapeutic use
Stomatitis, Aphthous*/drug therapy
Adult ; Child ; Double-Blind Method ; Humans ; Pain ; Tablets
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Contributed Indexing:: Keywords: Aphthous; Lactobacillus; Probiotics; Randomized controlled trial
Molecular Sequence:: ClinicalTrials.gov NCT04383236
Substance Nomenclature:: 0 (Tablets)
Entry Date(s):: Date Created: 20200822 Date Completed: 20210318 Latest Revision: 20210318
Update Code:: 20240105
DOI:: 10.1007/s00784-020-03527-7
PMID:: 32820431
: Czasopismo naukowe

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Objectives: The study aimed to explore the effectiveness of probiotics in the treatment of minor recurrent aphthous stomatitis (RAS).
Materials and Methods: We performed a randomized, controlled clinical study. Sixty adult (group A) and 60 children patients (group B) with diagnosis of minor RAS were included. Both groups were divided into two subgroups; AI and BI (test subgroups) and AII and BII (control subgroups). For test subgroups, probiotic lozenges were consecutively administered twice daily, for 5 days. The size and pain level of ulcers were recorded on treatment days 0, 3, and 5. The outbreak frequency of RAS within 6 months was investigated for all subgroups.
Results: Compared with baseline, an improvement was evident for all subgroups. However, for effectiveness in pain reduction, a statistically significant difference in favor of AI was observed for all evaluation periods when compared with control subgroup. Regarding effectiveness in ulcer size reduction, a statistically significant difference in favor of BI was observed at day 5 when compared with control subgroup. No significant difference was observed in the effectiveness index between subgroups AI and BI (test subgroups) except in effectiveness in pain reduction at day 3. The outbreak frequency decreased significantly in subgroup BI.
Conclusions: Topical application of probiotics decreased pain intensity and accelerates RAS healing. The effectiveness in pain reduction is more evident in adult patients while acceleration of healing is more evident in children.
Clinical Relevance: Probiotics could be a well-tolerated, topical therapeutic agent in the treatment of minor RAS.
Trial Registration: ClinicalTrials.gov ID: NCT04383236.

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