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Tytuł pozycji:

Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample.

Tytuł :
Associations between aversive learning processes and transdiagnostic psychiatric symptoms in a general population sample.
Autorzy :
Wise T; Wellcome Centre for Human Neuroimaging, University College London, London, UK. .; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK. .; Division of the Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA. .
Dolan RJ; Wellcome Centre for Human Neuroimaging, University College London, London, UK.; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
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Źródło :
Nature communications [Nat Commun] 2020 Aug 21; Vol. 11 (1), pp. 4179. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: [London] : Nature Pub. Group
MeSH Terms :
Affect*
Anxiety/*diagnosis
Anxiety/*psychology
Mental Disorders/*diagnosis
Adolescent ; Adult ; Aged ; Anxiety Disorders ; Bayes Theorem ; Computational Biology ; Fear ; Female ; Humans ; Learning ; Male ; Middle Aged ; Uncertainty ; Young Adult
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Grant Information :
United Kingdom WT_ Wellcome Trust; 203147/Z/16/Z United Kingdom WT_ Wellcome Trust; 206460/17/Z United Kingdom WT_ Wellcome Trust; 098362/Z/12/Z United Kingdom WT_ Wellcome Trust
Entry Date(s) :
Date Created: 20200823 Date Completed: 20200914 Latest Revision: 20200914
Update Code :
20201023
PubMed Central ID :
PMC7443146
DOI :
10.1038/s41467-020-17977-w
PMID :
32826918
Czasopismo naukowe
Symptom expression in psychiatric conditions is often linked to altered threat perception, however how computational mechanisms that support aversive learning relate to specific psychiatric symptoms remains undetermined. We answer this question using an online game-based aversive learning task together with measures of common psychiatric symptoms in 400 subjects. We show that physiological symptoms of anxiety and a transdiagnostic compulsivity-related factor are associated with enhanced safety learning, as measured using a probabilistic computational model, while trait cognitive anxiety symptoms are associated with enhanced learning from danger. We use data-driven partial least squares regression to identify two separable components across behavioural and questionnaire data: one linking enhanced safety learning and lower estimated uncertainty to physiological anxiety, compulsivity, and impulsivity; the other linking enhanced threat learning and heightened uncertainty estimation to symptoms of depression and social anxiety. Our findings implicate aversive learning processes in the expression of psychiatric symptoms that transcend diagnostic boundaries.

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