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Tytuł:
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Deep brain stimulation and recordings: Insights into the contributions of subthalamic nucleus in cognition.
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Autorzy:
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Drummond NM; Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada. Electronic address: .
Chen R; Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada.
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Źródło:
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NeuroImage [Neuroimage] 2020 Nov 15; Vol. 222, pp. 117300. Date of Electronic Publication: 2020 Aug 21.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Orlando, FL : Academic Press, c1992-
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MeSH Terms:
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Deep Brain Stimulation*/methods
Cognition/*physiology
Subthalamic Nucleus/*physiology
Basal Ganglia/physiology ; Female ; Humans ; Male ; Parkinson Disease/physiopathology ; Task Performance and Analysis
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Grant Information:
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MFE-164728 Canada CIHR; FDN 154292 Canada CIHR
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Contributed Indexing:
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Keywords: Basal ganglia; Cognition; Deep brain stimulation; Local field potential; Subthalamic nucleus
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Entry Date(s):
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Date Created: 20200824 Date Completed: 20210329 Latest Revision: 20210329
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Update Code:
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20240105
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DOI:
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10.1016/j.neuroimage.2020.117300
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PMID:
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32828919
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Recent progress in targeted interrogation of basal ganglia structures and networks with deep brain stimulation in humans has provided insights into the complex functions the subthalamic nucleus (STN). Beyond the traditional role of the STN in modulating motor function, recognition of its role in cognition was initially fueled by side effects seen with STN DBS and later revealed with behavioral and electrophysiological studies. Anatomical, clinical, and electrophysiological data converge on the view that the STN is a pivotal node linking cognitive and motor processes. The goal of this review is to synthesize the literature to date that used DBS to examine the contributions of the STN to motor and non-motor cognitive functions and control. Multiple modalities of research have provided us with an enhanced understanding of the STN and reveal that it is critically involved in motor and non-motor inhibition, decision-making, motivation and emotion. Understanding the role of the STN in cognition can enhance the therapeutic efficacy and selectivity not only for existing applications of DBS, but also in the development of therapeutic strategies to stimulate aberrant circuits to treat non-motor symptoms of Parkinson's disease and other disorders.
Competing Interests: Declaration of Competing Interest The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article.
(Copyright © 2020. Published by Elsevier Inc.)
