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Tytuł pozycji:

Deferoxamine produces nitric oxide under ferricyanide oxidation, blood incubation, and UV-irradiation.

Tytuł :
Deferoxamine produces nitric oxide under ferricyanide oxidation, blood incubation, and UV-irradiation.
Autorzy :
Mukosera GT; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA.
Liu T; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA.
Manaen M; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA.
Zhu L; Department of Chemistry, University of California-Riverside 501 Big Springs Road, Riverside, CA 92521, USA.
Power G; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA.
Schroeder H; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA.
Blood AB; Lawrence D Longo Center for Perinatal Biology and Department of Pediatrics, Loma Linda University, 11175 Campus Street, Loma Linda, CA, 92354, USA. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2020 Nov 20; Vol. 160, pp. 458-470. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Język :
English
Imprint Name(s) :
Publication: Tarrytown, NY : Elsevier Science
Original Publication: New York : Pergamon, c1987-
Contributed Indexing :
Keywords: Deferoxamine*; Ferricyanide*; Iron nitrosyl hemoglobin*; Nitric oxide*
Entry Date(s) :
Date Created: 20200824 Latest Revision: 20210309
Update Code :
20210309
DOI :
10.1016/j.freeradbiomed.2020.08.004
PMID :
32828952
Czasopismo naukowe
Deferoxamine (DFO), an iron chelator, is used therapeutically for the removal of excess iron in multiple clinical conditions such as beta thalassemia and intracerebral hemorrhage. DFO is also used as an iron chelator and hypoxia-mimetic agent in in vivo and in vitro basic research. Here we unexpectedly discover DFO to be a nitric oxide (NO) precursor in experiments where it was intended to act as an iron chelator. Production of NO from aqueous solutions of DFO was directly observed by ozone-based chemiluminescence using a ferricyanide-based assay and was confirmed by electron paramagnetic resonance (EPR). DFO also produced NO following exposure to ultraviolet light, and its incubation with sheep adult and fetal blood resulted in considerable formation of iron nitrosyl hemoglobin, as confirmed by both visible spectroscopy and EPR. These results suggest that experiments using DFO can be confounded by concomitant production of NO, and offer new insight into some of DFO's unexplained clinical side effects such as hypotension.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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