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Tytuł:
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Photocurable Biopolymers for Coaxial Bioprinting.
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Autorzy:
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Costantini M; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Barbetta A; Department of Chemistry, Sapienza University of Rome, Rome, Italy.
Swieszkowski W; Warsaw University of Technology, Warsaw, Poland.
Seliktar D; Faculty of Biomedical Engineering, TECHNION Israel Institute of Technology, Haifa, Israel.
Gargioli C; University of Rome 'Tor Vergata', Rome, Italy.
Rainer A; Università Campus Bio-Medico di Roma, Rome, Italy. .
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Źródło:
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Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2147, pp. 45-54.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
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MeSH Terms:
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Printing, Three-Dimensional*
Biopolymers/*chemistry
Bioprinting/*methods
Polymethacrylic Acids/*chemical synthesis
Tissue Scaffolds/*chemistry
Biopolymers/radiation effects ; Bioprinting/instrumentation ; Chondroitin Sulfates/chemistry ; Fibrinogen/chemistry ; Gelatin/chemistry ; Humans ; Hyaluronic Acid/chemistry ; Hydrogels/chemistry ; Ink ; Light ; Photochemical Processes ; Polyethylene Glycols/chemistry ; Polymethacrylic Acids/chemistry ; Surface Properties/radiation effects ; Tissue Engineering/instrumentation ; Tissue Engineering/methods
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Contributed Indexing:
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Keywords: Alginate; Bioink formulation; Coaxial bioprinting; Photocurable polymers
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Substance Nomenclature:
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0 (Biopolymers)
0 (Hydrogels)
0 (Polymethacrylic Acids)
3WJQ0SDW1A (Polyethylene Glycols)
9000-70-8 (Gelatin)
9001-32-5 (Fibrinogen)
9004-61-9 (Hyaluronic Acid)
9007-28-7 (Chondroitin Sulfates)
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Entry Date(s):
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Date Created: 20200826 Date Completed: 20210318 Latest Revision: 20210318
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Update Code:
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20240105
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DOI:
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10.1007/978-1-0716-0611-7_4
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PMID:
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32840809
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Thanks to their unique advantages, additive manufacturing technologies are revolutionizing almost all sectors of the industrial and academic worlds, including tissue engineering and regenerative medicine. In particular, 3D bioprinting is rapidly emerging as a first-choice approach for the fabrication-in one step-of advanced cell-laden hydrogel constructs to be used for in vitro and in vivo studies. This technique consists in the precise deposition layer-by-layer of sub-millimetric hydrogel strands in which living cells are embedded. A key factor of this process consists in the proper formulation of the hydrogel precursor solution, the so-called bioink. Ideal bioinks should be able, on the one side, to support cell growth and differentiation and, on the other, to allow the high-resolution deposition of cell-laden hydrogel strands. The latter feature requires the extruded solution to instantaneously undergo a sol-gel transition to avoid its collapse after deposition.To address this challenge, researchers are recently focusing their attention on the synthesis of several derivatives of natural biopolymers to enhance their printability. Here, we present an approach for the synthesis of photocurable derivatives of natural biopolymers-namely, gelatin methacrylate, hyaluronic acid methacrylate, chondroitin sulfate methacrylate, and PEGylated fibrinogen-that can be used to formulate tailored innovative bioinks for coaxial-based 3D bioprinting applications.