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Tytuł pozycji:

Control over Polymorph Formation of Polydatin in Binary Solvent System and Structural Characterization.

Tytuł:
Control over Polymorph Formation of Polydatin in Binary Solvent System and Structural Characterization.
Autorzy:
Gong N; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wang X; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wang Y; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yang S; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Song J; Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, 100050, China.
Lu Y; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
Du G; Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, 100050, China. Electronic address: .
Źródło:
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2020 Oct 25; Vol. 190, pp. 113260. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2006->: London : Elsevier Science
Original Publication: Oxford ; New York : Pergamon Press, c1983-
MeSH Terms:
Glucosides*
Solvents*
Stilbenes*
Calorimetry, Differential Scanning ; Crystallization ; Crystallography, X-Ray ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Contributed Indexing:
Keywords: Characterization; Pharmacokinetic study; Polydatin; Polymorphism; X-ray diffractometry
Substance Nomenclature:
0 (Glucosides)
0 (Solvents)
0 (Stilbenes)
XM261C37CQ (polydatin)
Entry Date(s):
Date Created: 20200827 Date Completed: 20210517 Latest Revision: 20210517
Update Code:
20240105
DOI:
10.1016/j.jpba.2020.113260
PMID:
32846398
Czasopismo naukowe
Polydatin is a natural product used for anti-oxidant, anti-inflammatory and anti-tumor purposes, and often added in medicine, nutraceutical, cosmetics, and dietary supplement. Polymorphism is a key feature of solid-state pharmaceutical products. Polymorphic modifications may exhibit different physical and chemical properties. Here we report two different polymorphs, and the amorphous form of Polydatin. Polymorphs were prepared in binary solvent system. The crystal structures of the two forms were revealed for the first time. The structure and 3D packing were determined with single crystal X-ray diffraction analysis. The batch consistency and stability were identified with Powder X-ray diffraction analysis. Various functional groups present in the polymorphs were analyzed with fourier transform infrared spectroscopic method. The thermal properties were investigated with DSC and TGA. HPLC-MS was used for the pharmacokinetic study. Results show that form B has the faster absorption, and can be maintained in animal bodies for a longer time than form A.
Competing Interests: Declaration of Competing Interest The authors have no potential conflicts of interest to disclose.
(Copyright © 2020. Published by Elsevier B.V.)

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