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Tytuł pozycji:

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.

Tytuł :
Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors.
Autorzy :
Alfinito E; Department for Innovation Engineering, University of Salento, Piazza Tancredi, I-73100 Lecce, Italy.
Beccaria M; Department of Mathematics and Physics 'Ennio de Giorgi', University of Salento, Piazza Tancredi, I-73100 Lecce, Italy.; National Institute for Nuclear Physics, I.N.F.N, Lecce Unit, I-73100 Lecce, Italy.
Ciccarese M; Oncology Unit 'Vito Fazzi' Hospital-Lecce, I-73100 Lecce, Italy.
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Źródło :
Biosensors [Biosensors (Basel)] 2020 Aug 24; Vol. 10 (9). Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Comparative Study; Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Basel, Switzerland : MDPI Pub.
MeSH Terms :
Biosensing Techniques/*methods
Interleukin-6/*analysis
Receptors, Interleukin-6/*analysis
Antibodies, Monoclonal/analysis ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized/chemistry ; Antibodies, Monoclonal, Humanized/immunology ; Aptamers, Nucleotide/chemistry ; Betacoronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Humans ; Immunoglobulin Fab Fragments/analysis ; Immunoglobulin Fab Fragments/immunology ; Interleukin-6/immunology ; Limit of Detection ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Receptors, Interleukin-6/immunology
References :
J Phys Chem B. 2019 Feb 14;123(6):1265-1273. (PMID: 30642170)
Autoimmun Rev. 2020 Jul;19(7):102568. (PMID: 32376398)
Biosens Bioelectron. 2019 Jul 15;137:123-132. (PMID: 31085401)
Cancer Cell. 2009 Feb 3;15(2):79-80. (PMID: 19185839)
Annu Rev Immunol. 2005;23:1-21. (PMID: 15771564)
Biosens Bioelectron. 2017 Jul 15;93:170-175. (PMID: 27660015)
MAbs. 2014 May-Jun;6(3):774-82. (PMID: 24670876)
Cancer Treat Rev. 2012 Nov;38(7):904-10. (PMID: 22651903)
Biochem J. 1990 Feb 1;265(3):621-36. (PMID: 1689567)
Oncogene. 2000 May 15;19(21):2548-56. (PMID: 10851053)
Biosens Bioelectron. 2011 Jul 15;26(11):4411-6. (PMID: 21636260)
Chem Soc Rev. 2010 Feb;39(2):734-49. (PMID: 20111790)
Curr Opin Pharmacol. 2012 Aug;12(4):464-70. (PMID: 22819198)
Biosens Bioelectron. 2016 Nov 15;85:32-45. (PMID: 27155114)
Cancer Med. 2017 Mar;6(3):640-650. (PMID: 28211615)
Exp Mol Med. 2016 May 06;48:e230. (PMID: 27151454)
Cancer Cell. 2008 Jan;13(1):7-9. (PMID: 18167335)
J Clin Invest. 2011 Sep;121(9):3375-83. (PMID: 21881215)
Clin Exp Rheumatol. 2020 May-Jun;38(3):529-532. (PMID: 32359035)
Science. 2020 May 1;368(6490):473-474. (PMID: 32303591)
Cytokine. 2014 Nov;70(1):11-20. (PMID: 24986424)
Curr Opin Chem Biol. 2010 Aug;14(4):467-74. (PMID: 20663707)
Nucleic Acids Res. 2000 Jan 1;28(1):235-42. (PMID: 10592235)
Science. 1990 Aug 3;249(4968):505-10. (PMID: 2200121)
J Biol Chem. 2014 Mar 21;289(12):8706-19. (PMID: 24415766)
J Biol Chem. 2014 Mar 21;289(12):8720-34. (PMID: 24415767)
Nucleic Acid Ther. 2016 Feb;26(1):10-9. (PMID: 26579954)
PLoS One. 2010 Dec 07;5(12):e15004. (PMID: 21165148)
Biomol Eng. 2007 Jun;24(2):191-200. (PMID: 17434340)
Comput Biol Chem. 2018 Dec;77:123-130. (PMID: 30308477)
Curr Pharm Des. 2011;17(4):340-6. (PMID: 21375496)
Nat Immunol. 2015 May;16(5):448-57. (PMID: 25898198)
Cancer Res. 1993 Feb 15;53(4):851-6. (PMID: 8428365)
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. (PMID: 12461182)
J Biol Chem. 2016 Jun 24;291(26):13846-54. (PMID: 27129274)
EMBO J. 1997 Mar 3;16(5):989-97. (PMID: 9118960)
Protein Eng Des Sel. 2016 Apr;29(4):123-33. (PMID: 26945588)
Nat Rev Immunol. 2018 May;18(5):309-324. (PMID: 29379212)
Curr Pharm Des. 2016;22(5):518-26. (PMID: 26601970)
Curr Opin Struct Biol. 2016 Feb;36:122-32. (PMID: 26919170)
Nanotechnology. 2017 Feb 10;28(6):065502. (PMID: 28050975)
Tumour Biol. 2016 Sep;37(9):11553-11572. (PMID: 27260630)
Science. 2003 Jun 27;300(5628):2101-4. (PMID: 12829785)
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Mar;91(3):032702. (PMID: 25871139)
Lancet. 2020 Mar 28;395(10229):1033-1034. (PMID: 32192578)
Trends Pharmacol Sci. 2007 Aug;28(8):397-406. (PMID: 17629961)
Curr Pharm Des. 2020;26(3):363-371. (PMID: 31942851)
Biophys J. 2005 Oct;89(4):2783-91. (PMID: 16192283)
Nucleic Acids Res. 2012 Sep;40(16):8119-28. (PMID: 22669903)
Adv Drug Deliv Rev. 2018 Sep;134:36-50. (PMID: 30321620)
Lancet Rheumatol. 2020 Jun;2(6):e325-e331. (PMID: 32501454)
Biochem Biophys Res Commun. 2011 Jul 22;411(1):102-6. (PMID: 21712027)
Grant Information :
FFABR 2017 Ministero dell'Istruzione, dell'Università e della Ricerca
Contributed Indexing :
Keywords: IL-6 cytokine; Proteotronics; aptamers; biosensors; topological analysis
Substance Nomenclature :
0 (Antibodies, Monoclonal)
0 (Antibodies, Monoclonal, Humanized)
0 (Aptamers, Nucleotide)
0 (Immunoglobulin Fab Fragments)
0 (Interleukin-6)
0 (Receptors, Interleukin-6)
PAI71R1D2W (olokizumab)
SCR Disease Name :
COVID-19
Entry Date(s) :
Date Created: 20200828 Date Completed: 20200902 Latest Revision: 20201023
Update Code :
20201023
PubMed Central ID :
PMC7557795
DOI :
10.3390/bios10090106
PMID :
32847008
Czasopismo naukowe
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.

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