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Tytuł:
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Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma.
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Autorzy:
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Heiland DH; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany. .; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany. .; Medical Faculty, Freiburg University, Freiburg, Germany. .
Ohle R; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Cipriani D; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Franco P; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Delev D; Department of Neurosurgery, University of Aachen, Aachen, Germany.
Behriger SP; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Kellner E; Medical Physics, Department of Radiology, Medical Centre - University of Freiburg, Freiburg, Germany.
Petrova G; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Neidert N; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Mader I; Clinic for Neuropediatrics and Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schön Klinik, Vogtareuth, Germany.
Nuñez MF; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Urbach H; Medical Faculty, Freiburg University, Freiburg, Germany.; Department of Neuroradiology, Medical Center - University of Freiburg, Freiburg, Germany.
Sankowski R; Medical Faculty, Freiburg University, Freiburg, Germany.; Institute of Neuropathology, Medical Center - University of Freiburg, Freiburg, Germany.; Berta-Ottenstein-Programme for Clinician Scientists Medical Center, University of Freiburg, Freiburg, Germany.
Beck J; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
Schnell O; Translational NeuroOncology Research Group, Medical Center, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center, University of Freiburg, Breisacher Straße 64, 79106, Freiburg, Germany.; Medical Faculty, Freiburg University, Freiburg, Germany.
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Źródło:
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BMC cancer [BMC Cancer] 2020 Aug 27; Vol. 20 (1), pp. 818. Date of Electronic Publication: 2020 Aug 27.
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Typ publikacji:
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Journal Article; Observational Study
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Język:
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English
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Imprint Name(s):
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Original Publication: London : BioMed Central, [2001-
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MeSH Terms:
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Astrocytoma/*diagnostic imaging
Brain Neoplasms/*diagnostic imaging
Magnetic Resonance Imaging/*methods
Neoplasm Recurrence, Local/*diagnostic imaging
Oligodendroglioma/*diagnostic imaging
Adult ; Aged ; Aged, 80 and over ; Astrocytoma/genetics ; Brain Neoplasms/genetics ; Chromosome Deletion ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 19/genetics ; Female ; Follow-Up Studies ; Humans ; Isocitrate Dehydrogenase/genetics ; Longitudinal Studies ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/genetics ; Neoplasm Staging ; Oligodendroglioma/genetics ; Retrospective Studies
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References:
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Contributed Indexing:
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Keywords: MR-imaging; Oligodendroglioma; Segmentation
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Substance Nomenclature:
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EC 1.1.1.41 (IDH2 protein, human)
EC 1.1.1.41 (Isocitrate Dehydrogenase)
EC 1.1.1.42. (IDH1 protein, human)
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Entry Date(s):
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Date Created: 20200829 Date Completed: 20210416 Latest Revision: 20220812
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Update Code:
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20240105
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PubMed Central ID:
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PMC7450792
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DOI:
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10.1186/s12885-020-07290-6
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PMID:
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32854646
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Background: Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10 and 20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients.
Methods: We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models.
Results: The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved.
Conclusions: Our data aids to improve the interpretation of MRI images in clinical practice.
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