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Tytuł:
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[Effect of electroacupuncture on liver surface blood perfusion and related indexes of oxidative stress in mice with acute alcoholic liver injury].
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Autorzy:
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Tang LM; Department of Acupuncture and Moxibustion, Hongdu Hospital of Traditional Chinese Medicine, Nanchang 330006, China; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medicinal Sciences, Beijing 100700.
Zhang D; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medicinal Sciences, Beijing 100700.
Li SY; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medicinal Sciences, Beijing 100700.
Wang SY; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medicinal Sciences, Beijing 100700.
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Źródło:
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Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2020 Aug 25; Vol. 45 (8), pp. 628-32.
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Typ publikacji:
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Journal Article
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Język:
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Chinese
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Imprint Name(s):
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Publication: Beijing : Institute Of Acupuncture And Moxibustion
Original Publication: Beijing, China : Published and distributed by World Books, [1980-
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MeSH Terms:
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Electroacupuncture*
Acupuncture Points ; Animals ; Liver ; Malondialdehyde ; Mice ; Oxidative Stress
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Contributed Indexing:
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Keywords: Acute alcoholic liver injury; Electroacupuncture; Liver surface blood perfusion; Malondialdehyde; Superoxide dismutase
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Substance Nomenclature:
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4Y8F71G49Q (Malondialdehyde)
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Entry Date(s):
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Date Created: 20200902 Date Completed: 20201009 Latest Revision: 20201009
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Update Code:
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20240104
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DOI:
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10.13702/j.1000-0607.190638
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PMID:
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32869572
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Objective: To observe the effect of electroacupuncture (EA) on liver surface blood perfusion and related indexes of oxidative stress in mice with acute alcoholic liver injury （AALI）, so as to explore its mechanism underlying improving of AALI.
Methods: Twenty-four Kunming mice were randomly divided into control, model and EA groups (8 mice/group). AALI model was established by intragastric administration of 50% ethanol at 6 g/kg. EA (4-6 V, 50 Hz) was applied to bilateral"Zusanli"(ST36) and"Taichong"(LR3) for 30 min. The liver surface blood perfusion was dynamically observed by moorFLPI laser speckle imager for 30 min. The morphological changes of the liver tissue were determined by H.E. staining. Levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver were measured by ELISA.
Results: Compared with the control group, the model group had markedly pathological changes of the hepatic cords, hepatic sinuses and hepatocytes shown by H.E. staining, a significant reduction in liver surface blood perfusion and the content of SOD in liver tissue ( P <0.01, P <0.05), and a significant increase in the content of MDA in liver tissue ( P <0.05). Compared with the model group, H.E. staining showed reduced pathological changes of the liver tissue, meanwhile the liver surface blood perfusion significant increased ( P <0.05) and the content of MDA in liver tissue significantly decreased ( P <0.01) in the EA group.
Conclusion: EA can improve the liver surface circulation of AALI mice, and regulate the oxidative stress response, and thus help to repair the damage of liver tissue.
